The association of leptin secretion with cognitive performance in patients with eating disorders

Wollenhaupt C, Wilke L, Erim Y, Rauh M, Steins-Loeber S, Paslakis G (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Psychiatry Research Elsevier

Book Volume: 276

Pages Range: 269-277

DOI: 10.1016/j.psychres.2019.05.001

Abstract

This study is an investigation of neuropsychological performance in patients with anorexia nervosa, bulimia nervosa, and binge eating disorder and hormonal secretion patterns for ghrelin, leptin, insulin, and glucose. An oral glucose tolerance test (OGTT)was performed in a cohort of n = 30 female patients suffering from eating disorders as well as n = 20 control females. All participants underwent the Wisconsin Card Sorting Test (WCST), the Trail Making Test (TMT), and a go/no-go task using food vs. neutral stimuli. Patients with anorexia nervosa differed from controls in their leptin response to the OGTT. While the four groups under investigation did not differ in neuropsychological performance, we found leptin responses to the OGTT to be associated with performance in the food-specific go/no-go task. These preliminary results may indicate a putative association between leptin concentrations and neuropsychological performance, particularly in measures of inhibitory control. Further studies investigating the role of leptin in impulsive behaviors in eating disorders would be useful.

Authors with CRIS profile

Yesim Erim Professur für Psychosomatik und Psychotherapie Manfred Rauh Department of Paediatrics and Adolescent Medicine

Involved external institutions

Otto-Friedrich-Universität Bamberg DE Germany (DE)

How to cite

APA:

Wollenhaupt, C., Wilke, L., Erim, Y., Rauh, M., Steins-Loeber, S., & Paslakis, G. (2019). The association of leptin secretion with cognitive performance in patients with eating disorders. Psychiatry Research, 276, 269-277. https://dx.doi.org/10.1016/j.psychres.2019.05.001

MLA:

Wollenhaupt, Carina, et al. "The association of leptin secretion with cognitive performance in patients with eating disorders." Psychiatry Research 276 (2019): 269-277.

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