Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry

Journal article

Publication Details

Author(s): Apfelbacher CJ, Ofenloch RF, Weisshaar E, Molin S, Bauer A, Mahler V, Heinrich A, Von Kiedrowski R, Schmitt J, Elsner P, Diepgen TL
Journal: Contact Dermatitis
Publication year: 2019
Volume: 80
Journal issue: 1
Pages range: 45-53
ISSN: 0105-1873


Background: The CARPE registry was set up in 2009 to prospectively investigate the management of patients with chronic hand eczema (CHE). Objectives: To report comprehensive follow-up data from the CARPE registry. Patients and methods: We investigated sociodemographic and clinical characteristics, provision of medical care, physician-assessed outcomes, and patient-reported outcomes (PROs). Data were collected between 2009 and 2016, with up to 5 years of follow-up, and are reported descriptively. Results: Overall, 1281 patients were included in the registry (53.7% female). Mean age was 47.0 years. Of the patients, 793 and 231 completed the 2-year follow-up and 5-year follow-up, respectively. At baseline, 5.4% had changed or given up their job because of CHE, the average duration of CHE was 6.1 years, and, in 22.4%, the CHE was severe according to physician global assessment. Systemic treatment (alitretinoin, acitretin, and methotrexate) was prescribed at least once to 39.0% of the patients during the course of the follow-up. Disease severity, quality of life and treatment satisfaction improved over time, and the proportion of patients receiving systemic treatments decreased. Conclusions: Under continued dermatological care, substantial improvements in disease severity and PROs over time was achieved during the course of the CARPE registry, even in patients with long-standing and severe hand eczema.

FAU Authors / FAU Editors

Mahler, Vera Prof. Dr.
Medizinische Fakultät

Additional Organisation

External institutions with authors

Co-med GmbH & Co.KG
Ludwig-Maximilians-Universität (LMU)
Ruprecht-Karls-Universität Heidelberg
Technische Universität Dresden
Universität Regensburg
Universitätsklinikum Jena

How to cite

Apfelbacher, C.J., Ofenloch, R.F., Weisshaar, E., Molin, S., Bauer, A., Mahler, V.,... Diepgen, T.L. (2019). Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry. Contact Dermatitis, 80(1), 45-53.

Apfelbacher, Christian J., et al. "Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry." Contact Dermatitis 80.1 (2019): 45-53.


Last updated on 2019-27-05 at 13:53