Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry

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Details zur Publikation

Autorinnen und Autoren: Apfelbacher CJ, Ofenloch RF, Weisshaar E, Molin S, Bauer A, Mahler V, Heinrich A, Von Kiedrowski R, Schmitt J, Elsner P, Diepgen TL
Zeitschrift: Contact Dermatitis
Jahr der Veröffentlichung: 2019
Band: 80
Heftnummer: 1
Seitenbereich: 45-53
ISSN: 0105-1873


Background: The CARPE registry was set up in 2009 to prospectively investigate the management of patients with chronic hand eczema (CHE). Objectives: To report comprehensive follow-up data from the CARPE registry. Patients and methods: We investigated sociodemographic and clinical characteristics, provision of medical care, physician-assessed outcomes, and patient-reported outcomes (PROs). Data were collected between 2009 and 2016, with up to 5 years of follow-up, and are reported descriptively. Results: Overall, 1281 patients were included in the registry (53.7% female). Mean age was 47.0 years. Of the patients, 793 and 231 completed the 2-year follow-up and 5-year follow-up, respectively. At baseline, 5.4% had changed or given up their job because of CHE, the average duration of CHE was 6.1 years, and, in 22.4%, the CHE was severe according to physician global assessment. Systemic treatment (alitretinoin, acitretin, and methotrexate) was prescribed at least once to 39.0% of the patients during the course of the follow-up. Disease severity, quality of life and treatment satisfaction improved over time, and the proportion of patients receiving systemic treatments decreased. Conclusions: Under continued dermatological care, substantial improvements in disease severity and PROs over time was achieved during the course of the CARPE registry, even in patients with long-standing and severe hand eczema.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Mahler, Vera Prof. Dr.
Medizinische Fakultät

Zusätzliche Organisationseinheit(en)

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Ludwig-Maximilians-Universität (LMU)
Ruprecht-Karls-Universität Heidelberg
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Universitätsklinikum Jena


Apfelbacher, C.J., Ofenloch, R.F., Weisshaar, E., Molin, S., Bauer, A., Mahler, V.,... Diepgen, T.L. (2019). Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry. Contact Dermatitis, 80(1), 45-53.

Apfelbacher, Christian J., et al. "Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry." Contact Dermatitis 80.1 (2019): 45-53.


Zuletzt aktualisiert 2019-27-05 um 13:53