Tissue sodium content in patients with type 2 diabetes mellitus

Journal article

Publication Details

Author(s): Kannenkeril D, Karg MV, Bosch A, Ott C, Linz P, Nagel AM, Uder M, Schmieder R
Journal: Journal of Diabetes and Its Complications
Publication year: 2019
ISSN: 1056-8727


Background: Tissue sodium content by
Na magnetic resonance imaging (MRI)has been found to be increased in arterial hypertension. We analyzed whether tissue sodium content is increased in patients with type-2 diabetes (T2DM). Methods: Patients with T2DM were compared to those with primary hypertension. Patients with T2DM were off any antidiabetic and hypertensive patients off any antihypertensive therapy for at least 4 weeks. Skin and muscle sodium content was assessed non-invasively with a 3.0 T clinical MRI system (Magnetom Verio, Siemens Health Care, Erlangen, Germany)in each patient. Results: In patients with T2DM (N = 59)we observed significantly greater muscle sodium content (diabetes: 20.6 ± 3.5 vs hypertension: 16.3 ± 2.5 mmol/l, p < 0.001)and skin sodium content (diabetes: 24.5 ± 7.2 vs hypertension: 20.6 ± 5.7 mmol/l, p = 0.01)than in those with primary hypertension (N = 33). When potential confounders (age, body mass index, gender, systolic and diastolic blood pressure, estimated glomerular filtration rate)were entered in a covariance analysis, both skin sodium content (p = 0.037)and muscle sodium content (p < 0.001)were still clearly elevated. Conclusion: Patients with T2DM have greater skin and muscle sodium content. These are the first known data to demonstrate increased tissue sodium content in patients with T2DM, measured by
Na magnetic resonance imaging. Since tissue sodium content is related to organ damage, therapeutic intervention should aim at reducing tissue sodium content.

FAU Authors / FAU Editors

Bosch, Agnes Dr. med.
Medizinische Klinik 4 - Nephrologie und Hypertensiologie
Linz, Peter Dr. rer. nat.
Radiologisches Institut
Nagel, Armin Michael Prof. Dr.
Professur für metabolische und funktionelle MR-Bildgebung
Ott, Christian PD Dr.
Medizinische Fakultät
Schmieder, Roland Prof. Dr.
Professur für Innere Medizin (Nephrologie)
Uder, Michael Prof. Dr.
Lehrstuhl für Diagnostische Radiologie

How to cite

Kannenkeril, D., Karg, M.V., Bosch, A., Ott, C., Linz, P., Nagel, A.M.,... Schmieder, R. (2019). Tissue sodium content in patients with type 2 diabetes mellitus. Journal of Diabetes and Its Complications. https://dx.doi.org/10.1016/j.jdiacomp.2019.04.006

Kannenkeril, Dennis, et al. "Tissue sodium content in patients with type 2 diabetes mellitus." Journal of Diabetes and Its Complications (2019).


Last updated on 2019-22-05 at 08:38