Tissue sodium content in patients with type 2 diabetes mellitus

Kannenkeril D, Karg MV, Bosch A, Ott C, Linz P, Nagel AM, Uder M, Schmieder R (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of Diabetes and Its Complications Elsevier

DOI: 10.1016/j.jdiacomp.2019.04.006

Abstract

Background: Tissue sodium content by ²³ Na magnetic resonance imaging (MRI)has been found to be increased in arterial hypertension. We analyzed whether tissue sodium content is increased in patients with type-2 diabetes (T2DM). Methods: Patients with T2DM were compared to those with primary hypertension. Patients with T2DM were off any antidiabetic and hypertensive patients off any antihypertensive therapy for at least 4 weeks. Skin and muscle sodium content was assessed non-invasively with a 3.0 T clinical MRI system (Magnetom Verio, Siemens Health Care, Erlangen, Germany)in each patient. Results: In patients with T2DM (N = 59)we observed significantly greater muscle sodium content (diabetes: 20.6 ± 3.5 vs hypertension: 16.3 ± 2.5 mmol/l, p < 0.001)and skin sodium content (diabetes: 24.5 ± 7.2 vs hypertension: 20.6 ± 5.7 mmol/l, p = 0.01)than in those with primary hypertension (N = 33). When potential confounders (age, body mass index, gender, systolic and diastolic blood pressure, estimated glomerular filtration rate)were entered in a covariance analysis, both skin sodium content (p = 0.037)and muscle sodium content (p < 0.001)were still clearly elevated. Conclusion: Patients with T2DM have greater skin and muscle sodium content. These are the first known data to demonstrate increased tissue sodium content in patients with T2DM, measured by ²³ Na magnetic resonance imaging. Since tissue sodium content is related to organ damage, therapeutic intervention should aim at reducing tissue sodium content.

Authors with CRIS profile

Agnes Bosch Department of Medicine 4 – Nephrology and Hypertension Christian Ott Medizinische Fakultät Peter Linz Institute of Radiology Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung Michael Uder Lehrstuhl für Diagnostische Radiologie Roland Schmieder Professur für Innere Medizin (Nephrologie)

How to cite

APA:

Kannenkeril, D., Karg, M.V., Bosch, A., Ott, C., Linz, P., Nagel, A.M.,... Schmieder, R. (2019). Tissue sodium content in patients with type 2 diabetes mellitus. Journal of Diabetes and Its Complications. https://dx.doi.org/10.1016/j.jdiacomp.2019.04.006

MLA:

Kannenkeril, Dennis, et al. "Tissue sodium content in patients with type 2 diabetes mellitus." Journal of Diabetes and Its Complications (2019).

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