Clinical Aspects of Transporter-Mediated Drug–Drug Interactions

Journal article
(Review article)


Publication Details

Author(s): Geßner A, König J, Fromm M
Journal: Clinical Pharmacology & Therapeutics
Publication year: 2019
ISSN: 0009-9236


Abstract

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma concentrations of the victim drug can be modified by drug–drug interactions occurring in enterocytes (e.g., P-glycoprotein), hepatocytes (e.g., organic anion-transporting polypeptide 1B1 (OATP1B1)), and/or renal proximal tubular cells (e.g., organic cation transporter 2 (OCT2)/multidrug and toxin extrusion 1 and 2-K (MATE1/MATE2-K)). In addition, transporter-mediated drug–drug interactions can cause altered local tissue concentrations and possibly altered effects/toxicity (e.g., in liver and kidneys). During drug development, there is now an intensive in vitro screening of new molecular entities as transporter substrates and inhibitors, followed if necessary by drug–drug interaction studies in healthy volunteers. Nevertheless, there are still unresolved issues, which will also be discussed in this review article (e.g., the clinical significance of transporter-mediated drug–drug interactions of particular relevance to the elderly who are prescribed multiple drugs, with additional impaired liver or kidney function, and the extent to which medication safety in real life could be improved by a reduction of those interactions).


FAU Authors / FAU Editors

Fromm, Martin Prof. Dr.
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie
Geßner, Arne Dr.
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie
König, Jörg Prof. Dr.
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie


How to cite

APA:
Geßner, A., König, J., & Fromm, M. (2019). Clinical Aspects of Transporter-Mediated Drug–Drug Interactions. Clinical Pharmacology & Therapeutics. https://dx.doi.org/10.1002/cpt.1360

MLA:
Geßner, Arne, Jörg König, and Martin Fromm. "Clinical Aspects of Transporter-Mediated Drug–Drug Interactions." Clinical Pharmacology & Therapeutics (2019).

BibTeX: 

Last updated on 2019-24-05 at 18:08