Microcracks in subchondral bone plate is linked to less cartilage damage

Zarka M, Hay E, Ostertag A, Marty C, Chappard C, Oudet F, Engelke K, Laredo JD, Cohen-Solal M (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Bone Elsevier

Book Volume: 123

Pages Range: 1-7

DOI: 10.1016/j.bone.2019.03.011

Abstract

Objectives: Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartilage and subchondral bone plate in relation to cartilage damage in humans and to better define the association of microcracks and osteocyte density in subchondral bone. Methods: We investigated 18 bone cores from cadaveric human knees that were stained with En-Bloc Basic Fuchsin. We quantified microcrack density, osteocyte density, cartilage surfaces and cartilage damage. The presence of microcracks was confirmed for each bone core by scanning electron microscopy. Finally, trabecular subchondral bone parameters were measured by micro-CT. Results: Microcracks were detected in both calcified cartilage and subchondral bone plate. The density of microcracks in both calcified cartilage (CC) and subchondral bone plate (SBP) was negatively correlated with cartilage damage (r = −0.45, p < 0.05). The presence of microcracks in SBP was associated with a lower histological OA score. Osteocytes formed a dendrite network that abruptly stopped at the border of calcified cartilage. Osteocyte density in subchondral bone plate was increased in the presence of microcracks in calcified cartilage. Conclusions: Subchondral bone plate microcracks might be required for maintaining cartilage homeostasis. Microcracks in calcified cartilage may trigger osteocyte density in subchondral bone plate with subsequent regulation of subchondral bone remodeling to prevent cartilage damage.

Authors with CRIS profile

Klaus Engelke Lehrstuhl für Medizinische Physik und Mikrogewebetechnik

Involved external institutions

University of Paris 7 - Denis Diderot / Université Paris VII Denis Diderot FR France (FR) Université de Technologie de Compiègne FR France (FR)

How to cite

APA:

Zarka, M., Hay, E., Ostertag, A., Marty, C., Chappard, C., Oudet, F.,... Cohen-Solal, M. (2019). Microcracks in subchondral bone plate is linked to less cartilage damage. Bone, 123, 1-7. https://dx.doi.org/10.1016/j.bone.2019.03.011

MLA:

Zarka, M., et al. "Microcracks in subchondral bone plate is linked to less cartilage damage." Bone 123 (2019): 1-7.

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