Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

Journal article


Publication Details

Author(s): Liberman K, Njemini R, Luiking Y, Forti LN, Verlaan S, Bauer JM, Memelink R, Brandt K, Donini LM, Maggio M, Mets T, Wijers SL, Sieber C, Cederholm T, Bautmans I
Journal: Aging Clinical and Experimental Research
Publication year: 2019
ISSN: 1594-0667


Abstract

Background: A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited. Aim: To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis. Methods: Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4–9) and a body mass index of 20–30 kg/m
2
were randomly allocated to two daily servings of active (n = 137, including 20 g of whey protein, 3 g of leucine and 800 IU VitD) or isocaloric control product (n = 151) for a double-blind period of 13 weeks. At baseline and after 13 weeks, circulating interleukin (IL)-8, IL-1 receptor antagonist (RA), soluble tumor-necrosis-factor receptor (sTNFR)1, IL-6, high-sensitivity C-reactive protein, pre-albumin and 25-hydroxyvitamin(OH)D were measured. Data-analysis included repeated measures analysis of covariance (corrected for dietary VitD intake) and linear regression. Results: IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p = 0.006 and p < 0.001, respectively). For IL-6 a significant time × treatment interaction (p = 0.046) was observed, with no significant change over time in the active group (p = 0.155) compared to control (significant increase p = 0.012). IL-8 showed an overall significant decrease (p = 0.03). The change in pre-albumin was a significant predictor for changes in IL-6 after 13 weeks. Conclusions: We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.


FAU Authors / FAU Editors

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)


External institutions with authors

Danone Nutricia Research
Free University Medical Center / VU Medisch Centrum
Newcastle University
Ruprecht-Karls-Universität Heidelberg
Università degli studi "La Sapienza"
University of Parma / Università degli Studi di Parma
Uppsala University Hospital / Akademiska sjukhuset
Vrije Universiteit Brussel


How to cite

APA:
Liberman, K., Njemini, R., Luiking, Y., Forti, L.N., Verlaan, S., Bauer, J.M.,... Bautmans, I. (2019). Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study. Aging Clinical and Experimental Research. https://dx.doi.org/10.1007/s40520-019-01208-4

MLA:
Liberman, Keliane, et al. "Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study." Aging Clinical and Experimental Research (2019).

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Last updated on 2019-23-05 at 14:53