Novel approach for the assessment of ovarian follicles infiltration in polymeric electrospun patterned scaffolds

Raffel N, Dittrich R, Bäuerle T, Seyler L, Amir F, Hoffmann I, Leal-Egaña A, Beckmann M, Boccaccini AR, Liverani L (2019)

Publication Type: Journal article

Publication year: 2019

Journal

PLoS ONE Public Library of Science

Book Volume: 14

Article Number: e0215985

Journal Issue: 4

DOI: 10.1371/journal.pone.0215985

Abstract

Reproductive tissue engineering (REPROTEN) has been recently defined as the application of the tissue engineering approach targeting reproductive organs and several research works are focusing on this novel strategy. Being still an innovative field, most of the scaffold characterization techniques suitable for other tissue targets give inappropriate results, and there is the need to evaluate and investigate novel approaches. In particular the focus of this paper is the evaluation of the infiltration of ovarian follicles inside patterned electrospun scaffolds. Beyond the standard techniques, for the first time the use of magnetic resonance imaging (MRI) for this purpose is proposed and specific protocols for scaffold preparation are reported. Positive results in terms of evaluation of scaffolds incorporating follicles confirm this technique as highly effective for further applications in this field.

Authors with CRIS profile

Nathalie Bleisinger Department of Obstetrics and Gynaecology Ralf Dittrich Professur für Experimentelle Reproduktionsmedizin Tobias Bäuerle Professur für Multimodale Bildgebung in der präklinischen Forschung Fattahi Amir Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

How to cite

APA:

Raffel, N., Dittrich, R., Bäuerle, T., Seyler, L., Amir, F., Hoffmann, I.,... Liverani, L. (2019). Novel approach for the assessment of ovarian follicles infiltration in polymeric electrospun patterned scaffolds. PLoS ONE, 14(4). https://doi.org/10.1371/journal.pone.0215985

MLA:

Raffel, Nathalie, et al. "Novel approach for the assessment of ovarian follicles infiltration in polymeric electrospun patterned scaffolds." PLoS ONE 14.4 (2019).

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