Alpha-Synuclein RNA Expression is Increased in Major Depression

Journal article

Publication Details

Author(s): Rotter A, Lenz B, Pitsch R, Richter-Schmidinger T, Kornhuber J, Rhein C
Journal: International Journal of Molecular Sciences
Publication year: 2019
Volume: 20
Journal issue: 8
ISSN: 1422-0067


Alpha-synuclein (SNCA) is a small membrane protein that plays an important role in neuro-psychiatric diseases. It is best known for its abnormal subcellular aggregation in Lewy bodies that serves as a hallmark of Parkinson's disease (PD). Due to the high comorbidity of PD with depression, we investigated the role of SNCA in patients suffering from major depressive disorder (MDD). SNCA mRNA expression levels were analyzed in peripheral blood cells of MDD patients and a healthy control group. SNCA mRNA expression was positively correlated with severity of depression as indicated by psychometric assessment. We found a significant increase in SNCA mRNA expression levels in severely depressed patients compared with controls. Thus, SNCA analysis could be a helpful target in the search for biomarkers of MDD.

FAU Authors / FAU Editors

Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Lenz, Bernd PD Dr.
Medizinische Fakultät
Rhein, Cosima PD Dr.
Psychiatrische und Psychotherapeutische Klinik

How to cite

Rotter, A., Lenz, B., Pitsch, R., Richter-Schmidinger, T., Kornhuber, J., & Rhein, C. (2019). Alpha-Synuclein RNA Expression is Increased in Major Depression. International Journal of Molecular Sciences, 20(8).

Rotter, Andrea, et al. "Alpha-Synuclein RNA Expression is Increased in Major Depression." International Journal of Molecular Sciences 20.8 (2019).


Last updated on 2019-21-05 at 10:23