Alpha-Synuclein RNA Expression is Increased in Major Depression

Rotter A, Lenz B, Pitsch R, Richter-Schmidinger T, Kornhuber J, Rhein C (2019)

Publication Type: Journal article

Publication year: 2019

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 20

Journal Issue: 8

DOI: 10.3390/ijms20082029

Abstract

Alpha-synuclein (SNCA) is a small membrane protein that plays an important role in neuro-psychiatric diseases. It is best known for its abnormal subcellular aggregation in Lewy bodies that serves as a hallmark of Parkinson's disease (PD). Due to the high comorbidity of PD with depression, we investigated the role of SNCA in patients suffering from major depressive disorder (MDD). SNCA mRNA expression levels were analyzed in peripheral blood cells of MDD patients and a healthy control group. SNCA mRNA expression was positively correlated with severity of depression as indicated by psychometric assessment. We found a significant increase in SNCA mRNA expression levels in severely depressed patients compared with controls. Thus, SNCA analysis could be a helpful target in the search for biomarkers of MDD.

Authors with CRIS profile

Andrea Rotter-Neubert Department of Psychiatry and Psychotherapy Bernd Lenz Medizinische Fakultät Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Cosima Rhein Department of Psychiatry and Psychotherapy

How to cite

APA:

Rotter, A., Lenz, B., Pitsch, R., Richter-Schmidinger, T., Kornhuber, J., & Rhein, C. (2019). Alpha-Synuclein RNA Expression is Increased in Major Depression. International Journal of Molecular Sciences, 20(8). https://doi.org/10.3390/ijms20082029

MLA:

Rotter, Andrea, et al. "Alpha-Synuclein RNA Expression is Increased in Major Depression." International Journal of Molecular Sciences 20.8 (2019).

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