Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein–expressing mice

Journal article


Publication Details

Author(s): Wihan J, Grosch J, Kalinichenko L, Müller CP, Winkler J, Kohl Z
Journal: Neurobiology of Aging
Publication year: 2019
Volume: 80
Pages range: 29-37
ISSN: 0197-4580


Abstract

Axonal pathology precedes dopaminergic cell loss in Parkinson's disease (PD), indicating a dying back axonopathy of nigrostriatal projections. Although most attention focused on the dopaminergic system, increasing evidence implies a compromised serotonergic system in PD as well. By combining immunohistological and biochemical approaches, a profound layer-specific reduction of the serotonergic input to the prefrontal cortex (PFC)layers II and V/VI in aged mutant A53T α-synuclein–expressing mice (A53T mice)was detected. In addition, the altered fiber network was characterized by swollen axons and enlarged axonal varicosities within all PFC layers, but most pronounced in PFC layer I. Although prefrontal serotonin levels and synaptic protein expression were preserved, aged A53T mice showed increased levels of kinesin family member 1a and vesicular monoamine transporter 2. Together with increased tryptophan hydroxylase 2 mRNA levels in the raphe nuclei and an elevated serotonin receptor 1b expression in the PFC, these findings point to compensatory mechanisms within the serotonergic system to overcome the reduced neuritic input to the PFC in this transgenic animal model for PD.


FAU Authors / FAU Editors

Grosch, Janina
Professur für Molekulare Neurologie
Kalinichenko, Liubov
Professur für Suchtmedizin
Kohl, Zacharias PD Dr.
Medizinische Fakultät
Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin
Wihan, Jeanette
Professur für Molekulare Neurologie
Winkler, Jürgen Prof. Dr.
Professur für Molekulare Neurologie


How to cite

APA:
Wihan, J., Grosch, J., Kalinichenko, L., Müller, C.P., Winkler, J., & Kohl, Z. (2019). Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein–expressing mice. Neurobiology of Aging, 80, 29-37. https://dx.doi.org/10.1016/j.neurobiolaging.2019.03.014

MLA:
Wihan, Jeanette, et al. "Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein–expressing mice." Neurobiology of Aging 80 (2019): 29-37.

BibTeX: 

Last updated on 2019-20-07 at 07:18