Electrospun Polyhydroxybutyrate/Poly(ϵ-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications

Journal article
(Original article)


Publication Details

Author(s): Ding Y, Li W, Correia A, Yang Y, Zheng K, Liu D, Schubert DW, Boccaccini AR, Santos HA, Roether J
Journal: ACS Applied Materials and Interfaces
Publisher: American Chemical Society
Publication year: 2018
Volume: 10
Journal issue: 17
Pages range: 14540-14548
ISSN: 1944-8244
Language: English


Abstract

Electrospun hybrid scaffolds are an effective platform to deliver drugs
site specifically for the prevention and treatment of diseases in
addition to promote tissue regeneration because of the flexibility to
load drugs therein. In the present study, electrospun hybrid scaffolds
containing antibiotics were developed to support cellular activities and
eliminate potential postoperative inflammation and infection. As a
model drug, levofloxacin (LFX) was successfully incorporated into pure
polyhydroxybutyrate/poly(ε-caprolactone) (PHB/PCL) scaffolds and
PHB/PCL/sol-gel-derived silica (SGS) scaffolds. The influence of LFX on
the morphology, mechanical performance, chemical structure, drug release
profile, and antibacterial effect of the scaffolds was thoroughly and
comparatively investigated. MG-63 osteoblast-like cell cultivation on
both scaffolds certified that LFX inclusion did not impair the
biocompatibility. In addition to the favorable cellular proliferation
and differentiation, scaffolds containing both LFX and SGS displayed
highly increased mineralization content. Therefore, the present
multifunctional hybrid scaffolds are promising in tissue engineering
applications.


FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Ding, Yaping
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Schubert, Dirk W. Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Zheng, Kai Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

Helsingin yliopisto / University of Helsinki


How to cite

APA:
Ding, Y., Li, W., Correia, A., Yang, Y., Zheng, K., Liu, D.,... Roether, J. (2018). Electrospun Polyhydroxybutyrate/Poly(ϵ-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications. ACS Applied Materials and Interfaces, 10(17), 14540-14548. https://dx.doi.org/10.1021/acsami.8b02656

MLA:
Ding, Yaping, et al. "Electrospun Polyhydroxybutyrate/Poly(ϵ-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications." ACS Applied Materials and Interfaces 10.17 (2018): 14540-14548.

BibTeX: 

Last updated on 2019-22-07 at 14:18