Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating

Journal article


Publication Details

Author(s): Nawaz Q, Ur Rehman MA, Roether J, Yufei L, Grünewald A, Detsch R, Boccaccini AR
Journal: Ceramics International
Publication year: 2019
ISSN: 0272-8842


Abstract

We investigated the bioactivity and cytocompatibility of 45S5 bioactive glass (BG) based scaffolds coated with a composite layer formed by gelatin and manganese doped mesoporous bioactive glass nanoparticles (Mn-MBGNs). The scaffolds were prepared using the foam replica method, and they were further coated with Mn-MBGNs/gelatin via dip coating. The synthesized scaffolds were characterized in relation to morphology, porosity, mechanical stability, bioactivity and cell biology behavior using osteoblast-like (MG-63) cells. The scaffolds were highly porous with interconnected porosity, and a suitable pore structure was maintained even after the Mn-MBGNs/gelatin coating. Energy-dispersive X-ray spectroscopy (EDX) confirmed the presence of Mn-MBGNs in the coatings. Moreover, the presence of gelatin was confirmed by Fourier transform infrared spectroscopy (FTIR). The coated scaffolds exhibited in-vitro bioactivity in simulated body fluid comparable to that of uncoated BG scaffolds. Finally, Mn-MBGNs/gelatin coated scaffolds were shown to be non-cytotoxic to MG-63 cells. Hence, the results presented here confirm that the novel Mn containing scaffolds can be considered in the field of biologically active ion releasing scaffolds for bone tissue engineering applications.


FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Nawaz, Qaisar
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Grünewald, Alina
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Ur Rehman, Muhammad Atiq
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


How to cite

APA:
Nawaz, Q., Ur Rehman, M.A., Roether, J., Yufei, L., Grünewald, A., Detsch, R., & Boccaccini, A.R. (2019). Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating. Ceramics International. https://dx.doi.org/10.1016/j.ceramint.2019.04.179

MLA:
Nawaz, Qaisar, et al. "Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating." Ceramics International (2019).

BibTeX: 

Last updated on 2019-15-05 at 13:53