Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Nawaz Q, Ur Rehman MA, Roether J, Yufei L, Grünewald A, Detsch R, Boccaccini AR
Zeitschrift: Ceramics International
Jahr der Veröffentlichung: 2019
ISSN: 0272-8842


Abstract

We investigated the bioactivity and cytocompatibility of 45S5 bioactive glass (BG) based scaffolds coated with a composite layer formed by gelatin and manganese doped mesoporous bioactive glass nanoparticles (Mn-MBGNs). The scaffolds were prepared using the foam replica method, and they were further coated with Mn-MBGNs/gelatin via dip coating. The synthesized scaffolds were characterized in relation to morphology, porosity, mechanical stability, bioactivity and cell biology behavior using osteoblast-like (MG-63) cells. The scaffolds were highly porous with interconnected porosity, and a suitable pore structure was maintained even after the Mn-MBGNs/gelatin coating. Energy-dispersive X-ray spectroscopy (EDX) confirmed the presence of Mn-MBGNs in the coatings. Moreover, the presence of gelatin was confirmed by Fourier transform infrared spectroscopy (FTIR). The coated scaffolds exhibited in-vitro bioactivity in simulated body fluid comparable to that of uncoated BG scaffolds. Finally, Mn-MBGNs/gelatin coated scaffolds were shown to be non-cytotoxic to MG-63 cells. Hence, the results presented here confirm that the novel Mn containing scaffolds can be considered in the field of biologically active ion releasing scaffolds for bone tissue engineering applications.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Grünewald, Alina
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Nawaz, Qaisar
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Ur Rehman, Muhammad Atiq
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


Zitierweisen

APA:
Nawaz, Q., Ur Rehman, M.A., Roether, J., Yufei, L., Grünewald, A., Detsch, R., & Boccaccini, A.R. (2019). Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating. Ceramics International. https://dx.doi.org/10.1016/j.ceramint.2019.04.179

MLA:
Nawaz, Qaisar, et al. "Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating." Ceramics International (2019).

BibTeX: 

Zuletzt aktualisiert 2019-15-05 um 13:53