Effects of renal denervation on blood pressure in hypertensive patients with end-stage renal disease: a single centre experience

Journal article


Publication Details

Author(s): Ott C, Schmid A, Ditting T, Veelken R, Uder M, Schmieder R
Journal: Clinical and Experimental Nephrology
Publication year: 2019
ISSN: 1342-1751


Abstract

Background: Sympathetic nerve activity is a hallmark of hypertension in end-stage renal disease (ESRD). An initial proof-of-concept study implies that renal denervation (RDN) is feasible and safe in RDN, but overall data are limited. Methods: In this single-centre prospective pilot study six patients with ESRD and treatment resistant hypertension were consecutively included. Ambulatory blood pressure (ABP) was measured before and 6 months after RDN (Symplictiy Flex™, Medtronic Inc., Santa Rosa, CA). Moreover, haemodialysis parameters which may affect BP reduction were monitored closely. Results: In all patients bilateral RDN was successful done, without documentation of peri- or postprocedural complications. There was a significant reduction in 24-h ABP by 20 ± 17/15 ± 12 mmHg 6 months after RDN (systolic: 163 ± 16 versus 143 ± 9 mmHg, p = 0.043; diastolic: 96 ± 9 versus 81 ± 15 mmHg, p = 0.043), with similar results for day-, and nighttime values, respectively. Antihypertensive medication was kept stable as well as there was no change in haemodialysis parameters during follow-up. In addition, ultrafiltration/week (1.4 ± 1.4 versus 2.2 ± 1.4 l, p = 0.08) as well as hematocrit (measured at baseline and 6 months after RDN) (33.7 ± 4.3 versus 33.1 ± 3.9%, p = 0.715) revealed no change in volume status. Conclusion: Our single-centre pilot study not only supports current data on renal safety of RDN even in small arteries of patients with ESRD, but also enhances the knowledge towards an effective ABP reduction in this type of hypertensive patients.


FAU Authors / FAU Editors

Ott, Christian PD Dr.
Medizinische Fakultät
Schmid, Axel PD Dr.
Radiologisches Institut
Schmieder, Roland Prof. Dr.
Professur für Innere Medizin (Nephrologie)
Uder, Michael Prof. Dr.
Lehrstuhl für Diagnostische Radiologie
Veelken, Roland Prof. Dr.
Medizinische Fakultät


How to cite

APA:
Ott, C., Schmid, A., Ditting, T., Veelken, R., Uder, M., & Schmieder, R. (2019). Effects of renal denervation on blood pressure in hypertensive patients with end-stage renal disease: a single centre experience. Clinical and Experimental Nephrology. https://dx.doi.org/10.1007/s10157-019-01697-7

MLA:
Ott, Christian, et al. "Effects of renal denervation on blood pressure in hypertensive patients with end-stage renal disease: a single centre experience." Clinical and Experimental Nephrology (2019).

BibTeX: 

Last updated on 2019-17-05 at 09:23