Analysis of Surface Levels of IL-1 Receptors and Macrophage Scavenger Receptor I in Peripheral Immune Cells of Patients With Alzheimer Disease

Journal article


Publication Details

Author(s): Spitzer P, Weinbeer J, Herrmann M, Oberstein T, Condic M, Lewczuk P, Kornhuber J, Maler JM
Journal: Journal of Geriatric Psychiatry and Neurology
Publication year: 2019
ISSN: 0891-9887


Abstract

Increased concentrations of interleukin 1 (IL-1) in the cerebrospinal fluid and serum of patients with Alzheimer disease (AD) reduced phagocytic capacity point to an inflammatory activation of mononuclear phagocytes in AD. Interleukin 1 receptors (IL-1R) and the macrophage scavenger receptor I (MSRI) are important players in IL-1 signaling and phagocytosis. In 20 patients with AD and 17 controls, IL-1RI, IL-1RII, and MSRI were assessed on peripheral blood mononuclear cells by flow cytometry. IL-1β, soluble IL-1 receptors, and IL-1R antagonist (IL-1Ra) were measured by enzyme-linked immunosorbent assay. The fraction of IL-1RI+ monocytes was increased by 10% and the expression of MSRI was reduced by 12% in AD. A 3.6% increased fraction of IL-1RI+ lymphocytes was accompanied by a 6.1% reduced expression of IL-1RII. The IL-1RI on monocytes and lymphocytes discriminated patients with AD with an accuracy of 0.79 and 0.75, respectively. The IL-1Ra was elevated in AD. Changes in the expression of IL-1 receptors and MSRI on peripheral blood cells fit to the concept of a proinflammatory state of the peripheral immune system. However, the observed differences are not strong enough to suggest their application as biomarkers for AD.


FAU Authors / FAU Editors

Condic, Mateja
Lehrstuhl für Psychiatrie und Psychotherapie
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Lewczuk, Piotr Prof. Dr.
Psychiatrische und Psychotherapeutische Klinik
Oberstein, Timo
Medizinische Fakultät
Spitzer, Philipp PD Dr.
Psychiatrische und Psychotherapeutische Klinik
Weinbeer, Johannes
Psychiatrische und Psychotherapeutische Klinik


How to cite

APA:
Spitzer, P., Weinbeer, J., Herrmann, M., Oberstein, T., Condic, M., Lewczuk, P.,... Maler, J.M. (2019). Analysis of Surface Levels of IL-1 Receptors and Macrophage Scavenger Receptor I in Peripheral Immune Cells of Patients With Alzheimer Disease. Journal of Geriatric Psychiatry and Neurology. https://dx.doi.org/10.1177/0891988719841728

MLA:
Spitzer, Philipp, et al. "Analysis of Surface Levels of IL-1 Receptors and Macrophage Scavenger Receptor I in Peripheral Immune Cells of Patients With Alzheimer Disease." Journal of Geriatric Psychiatry and Neurology (2019).

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Last updated on 2019-18-07 at 07:24