LDL cholesterol relates to depression, its severity, and the prospective course

Journal article


Publication Details

Author(s): Wagner C, Musenbichler C, Böhm L, Färber K, Fischer AI, von Nippold F, Winkelmann M, Richter-Schmidinger T, Mühle C, Kornhuber J, Lenz B
Journal: Progress in Neuro-Psychopharmacology & Biological Psychiatry
Publication year: 2019
Volume: 92
Pages range: 405-411
ISSN: 0278-5846


Abstract

Background: Major depressive disorder (MDD) is a highly prevalent and burdening mental illness. Approximately 30% of the major depressive episodes (MDE) are classified as therapy-refractory. Further knowledge of the pathophysiological mechanisms underlying MDD and predictive biomarkers are needed to improve treatment options. Methods: Serum lipid levels were compared between patients with a current MDE (n = 130) or remitted MDD (n = 39) and healthy control subjects (n = 61) and associated with the severity (17-item Hamilton Depression Rating Scale [HAMD] scores) and the prospective course of depression (direct follow-up of at median 20 days post-inclusion). Results: We found higher levels of LDL cholesterol (152.5 vs. 134.0 mg/dl, U = 3021, P = 0.008) and LDL/HDL ratio (2.82 vs. 2.21, U = 2912, P = 0.003) in patients with a current MDE than in healthy control subjects. In patients with a current MDE, higher HAMD scores correlated also with higher values of triglycerides (ρ = 0.213, P = 0.015), total cholesterol (ρ = 0.199, P = 0.023), LDL cholesterol (ρ = 0.224, P = 0.010), and LDL/HDL ratio (ρ = 0.196, P = 0.026). Moreover, higher total cholesterol (ρ = −0.233, P = 0.010), LDL cholesterol (ρ = 0.235, P = 0.010), and LDL/HDL ratio (ρ = −0.199, P = 0.029) were associated with a stronger decline in HAMD score between study inclusion and direct follow-up. Limitations: We employed an associational study design, performed only a short-term follow-up, and excluded suicidal study subjects. Conclusions: Serum lipid levels are associated with depression per se, the depression severity, and the prospective 3-week course. These observations build the basis for future investigations on individualized lipid metabolism-related treatment strategies in depressed patients.


FAU Authors / FAU Editors

Böhm, Lea
Lehrstuhl für Psychiatrie und Psychotherapie
Färber, Katharina
Lehrstuhl für Psychiatrie und Psychotherapie
Fischer, Anna-Isabell
Lehrstuhl für Psychiatrie und Psychotherapie
Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Lenz, Bernd PD Dr.
Medizinische Fakultät
Mühle, Christiane Dr. rer. nat.
Psychiatrische und Psychotherapeutische Klinik
Wagner, Claudia Dr. med.
Psychiatrische und Psychotherapeutische Klinik
Winkelmann, Merle
Kinder- und Jugendabteilung für Psychische Gesundheit in der Psychiatrischen und Psychotherapeutischen Klinik


How to cite

APA:
Wagner, C., Musenbichler, C., Böhm, L., Färber, K., Fischer, A.-I., von Nippold, F.,... Lenz, B. (2019). LDL cholesterol relates to depression, its severity, and the prospective course. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 92, 405-411. https://dx.doi.org/10.1016/j.pnpbp.2019.01.010

MLA:
Wagner, Claudia, et al. "LDL cholesterol relates to depression, its severity, and the prospective course." Progress in Neuro-Psychopharmacology & Biological Psychiatry 92 (2019): 405-411.

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Last updated on 2019-14-05 at 13:38