Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms

Capdevila J, Bodei L, Davies P, Gorbounova V, Jensen RT, Knigge UP, Krejs GJ, Krenning E, O'Connor JM, Peeters M, Rindi G, Salazar R, Vullierme MP, Arnold R, Bartsch D, Baudin E, Bodei L, Borbath , Capdevila J, Caplin M, Chen J, Costa F, Couvelard A, Cwikla JB, Davies P, De Herder WW, Falconi M, Falkerby J, Fazio N, Ferone D, Frilling A, Garcia-Carbonero R, Glasberg S, Gorbunova , Grossman A, Hoersch D, Jensen RT, Kaltsas G, Kloeppel G, Knigge UP, Kos-Kudla B, Krejs GJ, Krenning E, Kulke M, Lamberts SWJ, Van Dijkum NE, O'Connor JM, O'Toole D, Pape UF, Partelli S, Pavel ME, Peeters M, Ramage J, Reed NSB, Rindi G, Rinke A, Ruszniewski P, Sorbye H, Sundin A, Scoazec JY, Taal BG, Tiensuu JE, Toumpanakis C, Valle J, Vullierme MP, Welin S, Wiedenmann B (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 108

Pages Range: 18-25

Journal Issue: 1

DOI: 10.1159/000493319

Abstract

Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.

Authors with CRIS profile

Involved external institutions

Institut Gustave-Roussy France (FR) Università Vita-Salute San Raffaele (UniSR) Italy (IT) Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron Spain (ES) Memorial Sloan Kettering Cancer Center United States (USA) (US) University of Copenhagen Denmark (DK) Royal Free Hospital United Kingdom (GB) Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS) Russian Federation (RU) US National Institutes of Health (NIH) United States (USA) (US) Erasmus University Medical Center (MC) Netherlands (NL) Institute Alexander Fleming Argentina (AR) Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore Italy (IT) Antwerp University Hospital Belgium (BE) Catalan Institute of Oncology / Institut Català d'Oncologia (ICO) Spain (ES) Beaujon Hospital / Hôpital Beaujon France (FR) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Centre Hospitalier Universitaire de Montpellier (CHU/CHRU MTP) France (FR) Cliniques universitaires Saint-Luc (CHU St-Luc) Belgium (BE) Hôpital Bichat-Claude-Bernard (CHU, APHP) France (FR) Sun Yat-Sen University China (CN) Technische Universität München (TUM) Germany (DE) NHS Greater Glasgow and Clyde United Kingdom (GB) National and Kapodistrian University of Athens Greece (GR) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) University of Warmia and Mazury in Olsztyn Poland (PL) Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach (SUM) Poland (PL) Uppsala University Hospital / Akademiska sjukhuset Sweden (SE) University of Genova / Università degli Studi di Genova Italy (IT) Hospital Universitario 12 de Octubre Spain (ES) University of Rochester (UR) United States (USA) (US) Hebrew University of Jerusalem Israel (IL) Charité - Universitätsmedizin Berlin Germany (DE) Zentralklinikum Bad Berka Germany (DE) Dana–Farber Cancer Institute United States (USA) (US) St Vincent's University Hospital Ireland (IE) Uppsala University Sweden (SE) Haukeland University Hospital / Haukeland universitetssykehus Norway (NO) Netherlands Cancer Institute Netherlands (NL) Hampshire Hospitals NHS Foundation Trust United Kingdom (GB) University of Manchester United Kingdom (GB) Fondazione Policlinico Universitario Agostino Gemelli IRCCS Italy (IT) European Institute of Oncology / Istituto Europeo di Oncologia (IEO) Italy (IT)

How to cite

APA:

Capdevila, J., Bodei, L., Davies, P., Gorbounova, V., Jensen, R.T., Knigge, U.P.,... Wiedenmann, B. (2019). Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms. Neuroendocrinology, 108(1), 18-25. https://dx.doi.org/10.1159/000493319

MLA:

Capdevila, Jaume, et al. "Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms." Neuroendocrinology 108.1 (2019): 18-25.

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