Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms

Journal article

Publication Details

Author(s): Capdevila J, Bodei L, Davies P, Gorbounova V, Jensen RT, Knigge UP, Krejs GJ, Krenning E, O'Connor JM, Peeters M, Rindi G, Salazar R, Vullierme MP, Arnold R, Bartsch D, Baudin E, Bodei L, Borbath , Capdevila J, Caplin M, Chen J, Costa F, Couvelard A, Cwikla JB, Davies P, De Herder WW, Falconi M, Falkerby J, Fazio N, Ferone D, Frilling A, Garcia-Carbonero R, Glasberg S, Gorbunova , Grossman A, Hoersch D, Jensen RT, Kaltsas G, Kloeppel G, Knigge UP, Kos-Kudla B, Krejs GJ, Krenning E, Kulke M, Lamberts SWJ, Van Dijkum NE, O'Connor JM, O'Toole D, Pape UF, Partelli S, Pavel ME, Peeters M, Ramage J, Reed NSB, Rindi G, Rinke A, Ruszniewski P, Sorbye H, Sundin A, Scoazec JY, Taal BG, Tiensuu JE, Toumpanakis C, Valle J, Vullierme MP, Welin S, Wiedenmann B
Journal: Neuroendocrinology
Publication year: 2019
Volume: 108
Journal issue: 1
Pages range: 18-25
ISSN: 0028-3835


Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.

FAU Authors / FAU Editors

Pavel, Marianne Ellen
Medizinische Fakultät

External institutions with authors

Antwerp University Hospital
Beaujon Hospital / Hôpital Beaujon
Catalan Institute of Oncology / Institut Català d'Oncologia (ICO)
Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore
Charité - Universitätsmedizin Berlin
Cliniques universitaires Saint-Luc (CHU St-Luc)
Dana–Farber Cancer Institute
Erasmus University Medical Center
European Institute of Oncology / Istituto Europeo di Oncologia (IEO)
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hampshire Hospitals NHS Foundation Trust
Haukeland University Hospital / Haukeland universitetssykehus
Hebrew University of Jerusalem
Hôpital Bichat-Claude-Bernard (CHU, APHP)
Hospital Universitario 12 de Octubre
Imperial College London / The Imperial College of Science, Technology and Medicine
Institute Alexander Fleming
Institut Gustave-Roussy
Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach (SUM)
Memorial Sloan Kettering Cancer Center
National and Kapodistrian University of Athens
Netherlands Cancer Institute
NHS Greater Glasgow and Clyde
Royal Free Hospital
Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS)
St. Vincent’s University Hospital
Sun Yat-Sen University
Technische Universität München (TUM)
Universitätsklinikum Gießen und Marburg (UKGM)
Università Vita-Salute San Raffaele (UniSR)
University of Copenhagen
University of Genova / Università degli Studi di Genova
University of Manchester
University of Rochester (UR)
University of Warmia and Mazury in Olsztyn
Uppsala University
Uppsala University Hospital / Akademiska sjukhuset
US National Institutes of Health (NIH)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron
Zentralklinikum Bad Berka

How to cite

Capdevila, J., Bodei, L., Davies, P., Gorbounova, V., Jensen, R.T., Knigge, U.P.,... Wiedenmann, B. (2019). Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms. Neuroendocrinology, 108(1), 18-25. https://dx.doi.org/10.1159/000493319

Capdevila, Jaume, et al. "Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms." Neuroendocrinology 108.1 (2019): 18-25.


Last updated on 2019-29-05 at 06:53