Prognostic factors in ALS: a comparison between Germany and China

Journal article


Publication Details

Author(s): Dorst J, Chen L, Rosenbohm A, Dreyhaupt J, Hübers A, Schuster J, Weishaupt JH, Kassubek J, Gess B, Meyer T, Weyen U, Hermann A, Winkler J, Grehl T, Hagenacker T, Lingor P, Koch JC, Sperfeld A, Petri S, Großkreutz J, Metelmann M, Wolf J, Winkler AS, Klopstock T, Boentert M, Johannesen S, Storch A, Schrank B, Zeller D, Liu Xl, Tang L, Fan DS, Ludolph AC
Journal: Journal of Neurology
Publication year: 2019
ISSN: 0340-5354


Abstract

Objective: Several independent prognostic factors, such as age of onset, type of onset, body mass index (BMI), and progression rate have been identified for amyotrophic lateral sclerosis (ALS) in Caucasians. The aim of this study was to identify such factors in Chinese patients and to compare their impact with German patients. Methods: Comparison of prognostic factors was based on two hospital-based registries. The registry of the German Network for Motor Neuron Diseases contains 3100 patients with ALS. The Chinese registry comprises 2101 patients who were collected between 2003 and 2015 in the metropolitan area of Beijing. Results: Disease progression was slower in China [median loss of 0.50 points (IQR 0.26–0.87 points) versus 0.55 points (IQR 0.28–1.00 points) of ALS functional rating scale revised (ALS-FRS-R) score per month; p < 0.0001]. Survival of patients with ALS was similar in Germany and China (p > 0.05). We found that younger age of onset (p < 0.0001), spinal onset (p < 0.0001), high BMI (p < 0.0001) and low progression rate (p < 0.0001) were positive prognostic factors in China as well as in Germany. Interpretation: Prognostic factors, which are known to modify the course of disease in Caucasians, apply to Chinese patients as well. The results indicate that despite the apparent differences regarding genotype and clinical phenotype, findings from interventional studies in Caucasians aiming at disease-modifying prognostic factors (such as body weight) may be transferred to Chinese patients.


FAU Authors / FAU Editors

Winkler, Jürgen Prof. Dr.
Molekular-Neurologische Abteilung in der Neurologischen Klinik


External institutions with authors

Alfried Krupp Krankenhaus
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil
Fachklinik für Neurologie Dietenbronn GmbH
HELIOS Kliniken
Helmholtz-Zentrum für Umweltforschung GmbH (UFZ)
Julius-Maximilians-Universität Würzburg
Klinikum rechts der Isar
Ludwig-Maximilians-Universität (LMU)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
NeuroCure
Peking University (PKU) / 北京大学
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
RKU - Universitäts- und Rehabilitationskliniken Ulm
Universität Rostock
Universitätsklinikum Essen
Universitätsklinikum Göttingen
Universitätsklinikum Jena
Universitätsklinikum Leipzig
Universitätsklinikum Münster
Universitätsklinikum Regensburg


How to cite

APA:
Dorst, J., Chen, L., Rosenbohm, A., Dreyhaupt, J., Hübers, A., Schuster, J.,... Ludolph, A.C. (2019). Prognostic factors in ALS: a comparison between Germany and China. Journal of Neurology. https://dx.doi.org/10.1007/s00415-019-09290-4

MLA:
Dorst, Johannes, et al. "Prognostic factors in ALS: a comparison between Germany and China." Journal of Neurology (2019).

BibTeX: 

Last updated on 2019-23-05 at 02:08