The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study

Journal article

Publication Details

Author(s): Müller CP, Chu C, Qin L, Liu C, Xu B, Gao H, Ruggeri B, Hieber S, Schneider J, Jia T, Tay N, Akira S, Satoh T, Banaschewski T, Bokde AL, Bromberg U, Büchel C, Quinlan EB, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MLP, Artiges E, Lemaitre H, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Bakalkin G, Liu Y, Desrivières S, Elliott P, Eulenburg V, Levy D, Crews F, Schumann G
Journal: Cerebral Cortex
Publication year: 2019
Volume: 29
Journal issue: 4
Pages range: 1736-1751
ISSN: 1047-3211
eISSN: 1460-2199


Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, most studies reported changes in immune function that are secondary to alcohol use. In this report, we analyse how the gene "TRAF family member-associated NF-κB activator" (TANK) affects alcohol drinking behavior. Based on our recent discovery in a large GWAS dataset that suggested an association of TANK, SNP rs197273, with alcohol drinking, we report that SNP rs197273 in TANK is associated both with gene expression (P = 1.16 × 10-19) and regional methylation (P = 5.90 × 10-25). A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-κB. Functional and structural neuroimaging studies among up to 1896 adolescents reveal that TANK is involved in the control of brain activity in areas of aversive interoceptive processing, including the insular cortex, but not in areas related to reinforcement, reward processing or impulsiveness. Our findings suggest that the cortical neuroimmune regulator TANK is associated with enhanced aversive emotional processing that better protects from the establishment of alcohol drinking behavior.

FAU Authors / FAU Editors

Eulenburg, Volker PD Dr.
Lehrstuhl für Biochemie und Molekulare Medizin
Hieber, Saskia
Professur für Suchtmedizin
Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin
Schneider, Julia
Lehrstuhl für Biochemie und Molekulare Medizin

External institutions with authors

Commissariat à l'énergie atomique
Duke-NUS Medical School / 杜克—国大医学研究生院
École Polytechnique - Université Paris-Saclay
Fudan University / 复旦大学
Medical Research Council
National Heart, Lung, and Blood Institute
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
Northern Ontario School of Medicine / École de médecine du Nord de l'Ontario
Osaka University
Physikalisch-Technische Bundesanstalt (PTB)
Technische Universität Dresden
Trinity College Dublin
Universität Mannheim
Universitätsklinikum Göttingen
Universitätsklinikum Hamburg-Eppendorf
University of North Carolina at Chapel Hill
University of Nottingham
University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud
University of Vermont
Uppsala University

How to cite

Müller, C.P., Chu, C., Qin, L., Liu, C., Xu, B., Gao, H.,... Schumann, G. (2019). The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study. Cerebral Cortex, 29(4), 1736-1751.

Müller, Christian P., et al. "The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study." Cerebral Cortex 29.4 (2019): 1736-1751.


Last updated on 2019-09-08 at 11:32