Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality

Fejzo MS, Fasching P, Schneider M, Schwitulla J, Beckmann M, Schwenke E, Macgibbon KW, Mullin PM (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Geburtshilfe und Frauenheilkunde Georg Thieme Verlag

Book Volume: 79

Pages Range: 382-388

Journal Issue: 4

DOI: 10.1055/a-0830-1346

Abstract

Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity. Familial aggregation studies and twin studies suggest a genetic component. In a recent GWAS, we showed that placentation, appetite, and cachexia genes GDF15 and IGFBP7 are linked to hyperemesis gravidarum (HG). The purpose of this study is to determine whether GDF15 and IGFBP7 are upregulated in HG patients. Methods We compared serum levels of GDF15 and IGFBP7 at 12 and 24 weeks' gestation in women hospitalized for HG, and two control groups, women with nausea and vomiting of pregnancy (NVP), and women with no NVP. Results We show GDF15 and IGFBP7 serum levels are significantly increased in women with HG at 12 weeks' gestation. Serum levels of hCG are not significantly different between cases and controls. At 24 weeks gestation, when symptoms have largely resolved, there is no difference in GDF15 and IGFBP7 serum levels between cases and controls. Conclusion This study supports GDF15 and IGFBP7 in the pathogenesis of HG and may be useful for prediction and diagnosis. The GDF15-GFRAL brainstem-activated pathway was recently identified and therapies to treat conditions of abnormal appetite are under intense investigation. Based on our findings, HG should be included.

Authors with CRIS profile

Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Michael Schneider Department of Obstetrics and Gynaecology Judith Schwitulla Department of Obstetrics and Gynaecology Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde

Involved external institutions

University of California Los Angeles (UCLA) US United States (USA) (US) HER - Hyperemesis Education Research US United States (USA) (US) Keck School of Medicine of USC US United States (USA) (US)

How to cite

APA:

Fejzo, M.S., Fasching, P., Schneider, M., Schwitulla, J., Beckmann, M., Schwenke, E.,... Mullin, P.M. (2019). Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality. Geburtshilfe und Frauenheilkunde, 79(4), 382-388. https://doi.org/10.1055/a-0830-1346

MLA:

Fejzo, Marlena S., et al. "Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality." Geburtshilfe und Frauenheilkunde 79.4 (2019): 382-388.

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