Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality

Journal article

Publication Details

Author(s): Fejzo MS, Fasching P, Schneider M, Schwitulla J, Beckmann M, Schwenke E, Macgibbon KW, Mullin PM
Journal: Geburtshilfe und Frauenheilkunde
Publication year: 2019
Volume: 79
Journal issue: 4
Pages range: 382-388
ISSN: 0016-5751


Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity. Familial aggregation studies and twin studies suggest a genetic component. In a recent GWAS, we showed that placentation, appetite, and cachexia genes GDF15 and IGFBP7 are linked to hyperemesis gravidarum (HG). The purpose of this study is to determine whether GDF15 and IGFBP7 are upregulated in HG patients. Methods We compared serum levels of GDF15 and IGFBP7 at 12 and 24 weeks' gestation in women hospitalized for HG, and two control groups, women with nausea and vomiting of pregnancy (NVP), and women with no NVP. Results We show GDF15 and IGFBP7 serum levels are significantly increased in women with HG at 12 weeks' gestation. Serum levels of hCG are not significantly different between cases and controls. At 24 weeks gestation, when symptoms have largely resolved, there is no difference in GDF15 and IGFBP7 serum levels between cases and controls. Conclusion This study supports GDF15 and IGFBP7 in the pathogenesis of HG and may be useful for prediction and diagnosis. The GDF15-GFRAL brainstem-activated pathway was recently identified and therapies to treat conditions of abnormal appetite are under intense investigation. Based on our findings, HG should be included.

FAU Authors / FAU Editors

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe
Schneider, Michael Dr. med.
Schwitulla, Judith

External institutions with authors

HER - Hyperemesis Education Research
Keck School of Medicine of USC
University of California Los Angeles (UCLA)

How to cite

Fejzo, M.S., Fasching, P., Schneider, M., Schwitulla, J., Beckmann, M., Schwenke, E.,... Mullin, P.M. (2019). Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality. Geburtshilfe und Frauenheilkunde, 79(4), 382-388.

Fejzo, Marlena S., et al. "Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality." Geburtshilfe und Frauenheilkunde 79.4 (2019): 382-388.


Last updated on 2019-29-05 at 14:23