Pathway-specific light adaptation in human electroretinograms

Brasil A, Tsai TI, da Silva Souza G, Herculano AM, Ventura DF, de Lima Silveira LC, Kremers J (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of Vision Association for Research in Vision and Ophthalmology (ARVO)

Book Volume: 19

Pages Range: 12-

Journal Issue: 3

DOI: 10.1167/19.3.12

Abstract

The cellular origins of slow ERG changes during light adaptation following a dark-adapted state are still unclear. To study light adaptation, six healthy, normal trichromats were dark-adapted for 30 min prior to full-field ERG recordings to sinusoidal stimuli that isolate responses of the L- or M-cones or that stimulate luminance and chromatic mechanisms at 12 or 36 Hz. Recordings were performed for 16 min with 2-min intervals after onset of a constant background. Generally, the responses were sine-wave-like, and the first harmonic (fundamental) component dominated the Fourier spectrum except for the 12-Hz luminance stimulus in which two components, a sine-wave-like component and a transient component, determined the response profiles, leading to large second harmonic components. The amplitude of the first harmonic component (F) increased as a function of the light-adaptation time except for the 12-Hz luminance stimulus at which the F component decreased as a function of the light-adaptation period. The phase of the first harmonic component changed only slightly (less than 30°) during the light-adaptation period for all stimuli conditions. The L/M ratio in luminance reflecting ERGs decreased with increasing adaptation time. Our present data suggest that the light-adaptation process mainly reflects changes in the luminance pathway. The responses to 12-Hz luminance stimuli are determined by two different luminance driven pathways with different adaptation characteristics.

Authors with CRIS profile

Jan Kremers Professur für Experimentelle Augenheilkunde

Involved external institutions

Universidade Federal do Pará (UFPA) BR Brazil (BR) University of São Paulo / Universidade de São Paulo (USP) BR Brazil (BR)

How to cite

APA:

Brasil, A., Tsai, T.I., da Silva Souza, G., Herculano, A.M., Ventura, D.F., de Lima Silveira, L.C., & Kremers, J. (2019). Pathway-specific light adaptation in human electroretinograms. Journal of Vision, 19(3), 12-. https://dx.doi.org/10.1167/19.3.12

MLA:

Brasil, Alódia, et al. "Pathway-specific light adaptation in human electroretinograms." Journal of Vision 19.3 (2019): 12-.

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