Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease
Hansson O, Lehmann S, Otto M, Zetterberg H, Lewczuk P (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 11
Pages Range: 1-15
Journal Issue: 1
DOI: 10.1186/s13195-019-0485-0
Abstract
The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ42), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau181) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer’s Disease (AD). In an effort to improve the accuracy of an AD diagnosis, it is important to be able to distinguish between AD and other types of dementia (non-AD). The concentration ratio of Aβ42 to Aβ40 (Aβ42/40 Ratio) has been suggested to be superior to the concentration of Aβ42 alone when identifying patients with AD. This article reviews the available evidence on the use of the CSF Aβ42/40 ratio in the diagnosis of AD. Based on the body of evidence presented herein, it is the conclusion of the current working group that the CSF Aβ42/40 ratio, rather than the absolute value of CSF Aβ42, should be used when analysing CSF AD biomarkers to improve the percentage of appropriately diagnosed patients.
Authors with CRIS profile
Involved external institutions
Lund University / Lunds universitet
Sweden (SE)
University of Montpellier / Université Montpellier
France (FR)
Universität Ulm
Germany (DE)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
Sweden (SE)
University of Montpellier / Université Montpellier
France (FR)
Universität Ulm
Germany (DE)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
How to cite
APA:
Hansson, O., Lehmann, S., Otto, M., Zetterberg, H., & Lewczuk, P. (2019). Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease. Alzheimer's Research and Therapy, 11(1), 1-15. https://doi.org/10.1186/s13195-019-0485-0
MLA:
Hansson, Oskar, et al. "Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease." Alzheimer's Research and Therapy 11.1 (2019): 1-15.
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