Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
Ramdhan ND, Blom J, Sutcliffe IC, Pereira-Ribeiro PM, Santos CS, Mattos-Guaraldi AL, Burkovski A, Sangal V (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 30
Article Number: 100544
DOI: 10.1016/j.nmni.2019.100544
Abstract
The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
Authors with CRIS profile
Involved external institutions
Rio de Janeiro State University / Universidade do Estado do Rio de Janeiro (UERJ)
Brazil (BR)
Northumbria University
United Kingdom (GB)
Kerckhoff-Klinik
Germany (DE)
Brazil (BR)
Northumbria University
United Kingdom (GB)
Kerckhoff-Klinik
Germany (DE)
How to cite
APA:
Ramdhan, N.D., Blom, J., Sutcliffe, I.C., Pereira-Ribeiro, P.M., Santos, C.S., Mattos-Guaraldi, A.L.,... Sangal, V. (2019). Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient. New Microbes and New Infections, 30. https://dx.doi.org/10.1016/j.nmni.2019.100544
MLA:
Ramdhan, N. D., et al. "Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient." New Microbes and New Infections 30 (2019).
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