Salivary biomarkers in psychoneuroimmunology

Journal article
(Review article)

Publication Details

Author(s): Engeland CG, Bosch JA, Rohleder N
Journal: Current Opinion in Behavioral Sciences
Publication year: 2019
Volume: 28
Pages range: 58-65
ISSN: 2352-1546


As molecular biology advances, an increasing number of proteins are becoming detectable at very low levels in different biological tissues. In this regard, saliva holds vast promise. Unlike blood, saliva can be sampled 1) non-invasively; 2) across all ages (newborn to elderly); 3) in the field; 4) by study participants; and 5) many times per day. With respect to psychoneuroimmunology (PNI), physiological measures of stress such as cortisol have been well characterized. Alpha amylase provides another physiological index of stress; it is a measure of autonomic nervous system activation and is quantifiable in saliva. Other salivary measures, such as inflammatory biomarkers and immunoglobulin A (IgA), provide valuable information pertaining to the effects of stress on inflammation, mucosal immunity, and oral health. Importantly, due to various methodological issues and a lack of strong correlation between saliva and blood measures, investigators should proceed with caution in drawing conclusions from measures of salivary inflammation that pertain to systemic immunity or generalized health.

FAU Authors / FAU Editors

Rohleder, Nicolas Prof. Dr.
Lehrstuhl für Gesundheitspsychologie

External institutions with authors

Academic Medical Centre / Academisch Medisch Centrum (AMC)
Pennsylvania State University (Penn State)

How to cite

Engeland, C.G., Bosch, J.A., & Rohleder, N. (2019). Salivary biomarkers in psychoneuroimmunology. Current Opinion in Behavioral Sciences, 28, 58-65.

Engeland, Christopher G., Jos A. Bosch, and Nicolas Rohleder. "Salivary biomarkers in psychoneuroimmunology." Current Opinion in Behavioral Sciences 28 (2019): 58-65.


Last updated on 2019-11-05 at 04:08