Chronic cerebral hypoperfusion-induced memory impairment and hippocampal long-term potentiation deficits are improved by cholinergic stimulation in rats

Journal article


Publication Details

Author(s): Damodaran T, Müller CP, Hassan Z
Journal: Pharmacological Reports
Publication year: 2019
Volume: 71
Pages range: 443-448
ISSN: 1734-1140


Abstract

Background: Chronic cerebral hypoperfusion (CCH) can induce the accumulation of reactive oxygen species, which leads to oxidative damage, neuronal injury, and central cholinergic dysfunction in vulnerable regions of the brain, such as the hippocampus and cerebral cortex. These effects can lead to significant cognitive impairments in clinical populations of vascular dementia (VaD). The present studies aimed to investigate the role of the cholinergic system in memory functions and hippocampal long-term potentiation (LTP) impairments induced by CCH in rats. Methods: Male Sprague Dawley rats were subjected to permanent bilateral occlusion of common carotid arteries (PBOCCA) or sham surgery. Then, PBOCCA rats received ip injections with, either vehicle (control group), the muscarinic receptor agonist oxotremorine (0.1 mg/kg), or the acetylcholinesterase inhibitor physostigmine (0.1 mg/kg). Cognitive functions were evaluated using a passive avoidance task and the Morris water maze test. In addition, hippocampal LTP was recorded in vivo under anaesthesia. Results: The PBOCCA rats exhibited significant deficits in passive avoidance retention and spatial learning and memory tests. They also showed a suppression of LTP formation in the hippocampus. Oxotremorine and physostigmine significantly improved the learning and memory deficits as well as the suppression of LTP in PBOCCA rats. Conclusions: The present data suggest that the cholinergic system plays an important role in CCH-induced cognitive deficits and could be an effective therapeutic target for the treatment of VaD.


FAU Authors / FAU Editors

Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin


External institutions with authors

University of Science Malaysia (USM) / Universiti Sains Malaysia


How to cite

APA:
Damodaran, T., Müller, C.P., & Hassan, Z. (2019). Chronic cerebral hypoperfusion-induced memory impairment and hippocampal long-term potentiation deficits are improved by cholinergic stimulation in rats. Pharmacological Reports, 71, 443-448. https://dx.doi.org/10.1016/j.pharep.2019.01.012

MLA:
Damodaran, Thenmoly, Christian P. Müller, and Zurina Hassan. "Chronic cerebral hypoperfusion-induced memory impairment and hippocampal long-term potentiation deficits are improved by cholinergic stimulation in rats." Pharmacological Reports 71 (2019): 443-448.

BibTeX: 

Last updated on 2019-03-05 at 09:38