Development of high-resolution 3D MR fingerprinting for detection and characterization of epileptic lesions
Ma D, Jones SE, Deshmane A, Sakaie K, Pierre EY, Larvie M, Mcgivney D, Blümcke I, Krishnan B, Lowe M, Gulani V, Najm I, Griswold MA, Wang ZI (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 49
Pages Range: 1333-1346
Journal Issue: 5
DOI: 10.1002/jmri.26319
Abstract
Background Conventional MRI can be limited in detecting subtle epileptic lesions or identifying active/epileptic lesions among widespread, multifocal lesions. Purpose We developed a high-resolution 3D MR fingerprinting (MRF) protocol to simultaneously provide quantitative T-1, T-2, proton density, and tissue fraction maps for detection and characterization of epileptic lesions. Study type Prospective. Population National Institute of Standards and Technology (NIST) / International Society for Magnetic Resonance in Medicine (ISMRM) phantom, five healthy volunteers and 15 patients with medically intractable epilepsy undergoing presurgical evaluation with noninvasive or invasive electroclinical data. Field Strength/Sequence 3D MRF scans and routine clinical epilepsy MR protocols were acquired at 3 T. Assessment The accuracy of the T-1 and T-2 values were first evaluated using the NIST/ISMRM phantom. The repeatability was then estimated with both phantom and volunteers based on the coefficient of variance (CV). For epilepsy patients, all the maps were qualitatively reviewed for lesion detection by three independent reviewers (S.E.J., M.L., I.N.) blinded to clinical data. Region of interest (ROI) analysis was performed on T-1 and T-2 maps to quantify the multiparametric signal differences between lesion and normal tissues. Findings from qualitative review and quantitative ROI analysis were compared with patients' electroclinical data to assess concordance. Statistical Tests Phantom results were compared using R-squared, and patient results were compared using linear regression models. Results The phantom study showed high accuracy with the standard values, with an R-2 of 0.99. The volunteer study showed high repeatability, with an average CV of 4.3% for T-1 and T-2 in various tissue regions. For the 15 patients, MRF showed additional findings in four patients, with the remaining 11 patients showing findings consistent with conventional MRI. The additional MRF findings were highly concordant with patients' electroclinical presentation. Data Conclusion The 3D MRF protocol showed potential to identify otherwise inconspicuous epileptogenic lesions from the patients with negative conventional MRI diagnosis, as well as to correlate with different levels of epileptogenicity when widespread lesions were present.
Authors with CRIS profile
Involved external institutions
Cleveland Clinic
United States (USA) (US)
Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics
Germany (DE)
The Florey Institute of Neuroscience and Mental Health
Australia (AU)
Case Western Reserve University
United States (USA) (US)
United States (USA) (US)
Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics
Germany (DE)
The Florey Institute of Neuroscience and Mental Health
Australia (AU)
Case Western Reserve University
United States (USA) (US)
How to cite
APA:
Ma, D., Jones, S.E., Deshmane, A., Sakaie, K., Pierre, E.Y., Larvie, M.,... Wang, Z.I. (2019). Development of high-resolution 3D MR fingerprinting for detection and characterization of epileptic lesions. Journal of Magnetic Resonance Imaging, 49(5), 1333-1346. https://doi.org/10.1002/jmri.26319
MLA:
Ma, Dan, et al. "Development of high-resolution 3D MR fingerprinting for detection and characterization of epileptic lesions." Journal of Magnetic Resonance Imaging 49.5 (2019): 1333-1346.
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