Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene

Journal article


Publication Details

Author(s): Wang AL, Chao OY, Yang YM, Trossbach SV, Müller CP, Korth C, Huston JP, De Souza Silva MA
Journal: Pharmacology Biochemistry and Behavior
Publication year: 2019
Volume: 179
Pages range: 73-79
ISSN: 0091-3057


Abstract

In humans, mutations in the Disrupted-in-schizophrenia 1 (DISC1) gene have been related to psychiatric disorders, including symptoms of abnormal cognitive and emotional behaviors. In our previous studies, overexpression of the human DISC1 gene in rats resulted in schizophrenia-like phenotypes showing deficits in motor learning, impaired cognitive function and dysfunctions of the dopamine system. Here we asked, whether the DISC1 overexpression affects locomotor activity in the open field (OF), anxiety in the elevated plus-maze (PPM), depression-related behavior in the forced swim test (FST), and attention-like/short-term working-memory in the spontaneous alternation behavior (SAB) in the T-maze in transgenic DISC1 (tgDISC1) rats and littermate controls (WT). TgDISC1 rats showed enhanced anxiety behavior in the EPM and an impairment in attention-like/short-term working-memory in the SAB. However, tgDISC1 animals showed no locomotor impairments or depression-like behavior in the OF and FST. These results suggest that DISC1 overexpression leads to higher anxiety level and an attention-like/working-memory deficit. These findings may expand the causal role of DISC1 in its contribution to multiple symptom dimensions of psychiatric disorders.


FAU Authors / FAU Editors

Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin


External institutions with authors

Heinrich-Heine-Universität Düsseldorf
University of Minnesota (UMN)


How to cite

APA:
Wang, A.-L., Chao, O.Y., Yang, Y.-M., Trossbach, S.V., Müller, C.P., Korth, C.,... De Souza Silva, M.A. (2019). Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene. Pharmacology Biochemistry and Behavior, 179, 73-79. https://dx.doi.org/10.1016/j.pbb.2019.02.005

MLA:
Wang, An-Li, et al. "Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene." Pharmacology Biochemistry and Behavior 179 (2019): 73-79.

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Last updated on 2019-30-04 at 12:08