The Impact of Hyperosmolality on Activation and Differentiation of B Lymphoid Cells

Journal article


Publication Details

Author(s): Cvetkovic L, Perisic S, Titze J, Jäck HM, Schuh W
Journal: Frontiers in Immunology
Publication year: 2019
Volume: 10
ISSN: 1664-3224


Abstract

B lymphocytes, as a central part of adaptive immune responses, have the ability to fight against an almost unlimited numbers of pathogens. Impairment of B cell development, activation and differentiation to antibody secreting plasma cells can lead to malignancy, allergy, autoimmunity and immunodeficiency. However, the impact of environmental factors, such as hyperosmolality or osmotic stress caused by varying salt concentrations in different lymphoid organs, on these processes is not well-understood. Here, we report that B cells respond to osmotic stress in a biphasic manner. Initially, increased osmolality boosted B cell activation and differentiation as shown by an untimely downregulation of Pax5 as well as upregulation of CD138. However, in the second phase, we observed an increase in cell death and impaired plasmablast differentiation. Osmotic stress resulted in impaired class switch to IgG1, inhibition of phosphorylation of p38 mitogen-activated kinase and a delayed NFAT5 response. Overall, these findings demonstrate the importance of microenvironmental hyperosmolality and osmotic stress caused by NaCl for B cell activation and differentiation.


FAU Authors / FAU Editors

Jäck, Hans-Martin Prof. Dr.
Molekular-Immunologische Abteilung in der Medizinischen Klinik 3
Schuh, Wolfgang Dr. rer. nat.
Molekular-Immunologische Abteilung in der Medizinischen Klinik 3
Titze, Jens Prof. Dr.
Medizinische Klinik 4 - Nephrologie und Hypertensiologie


How to cite

APA:
Cvetkovic, L., Perisic, S., Titze, J., Jäck, H.-M., & Schuh, W. (2019). The Impact of Hyperosmolality on Activation and Differentiation of B Lymphoid Cells. Frontiers in Immunology, 10. https://dx.doi.org/10.3389/fimmu.2019.00828

MLA:
Cvetkovic, Ljiljana, et al. "The Impact of Hyperosmolality on Activation and Differentiation of B Lymphoid Cells." Frontiers in Immunology 10 (2019).

BibTeX: 

Last updated on 2019-07-05 at 11:08