Grötsch B, Bozec A, Schett G (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 1914
Pages Range: 269-280
DOI: 10.1007/978-1-4939-8997-3_14
Rheumatoid arthritis (RA) models in mice induced by immunization enable the analyses of molecular mechanism involved in disease development, progression, and resolution of inflammation. Here, we describe three different models mimicking clinic symptoms of human rheumatoid arthritis, which could be transferable to any genetically modified mouse. We will present the protocol for collagen-induced arthritis (CIA), K/BxN serum-induced arthritis (SIA), and the antigen-induced arthritis (AIA) models. To do so, we will detail their way of induction but also how to analyze RA clinical score and pathology characterization. Finally, we will briefly discuss the main characteristics and disadvantages of all three models.
APA:
Grötsch, B., Bozec, A., & Schett, G. (2019). In Vivo Models of Rheumatoid Arthritis. Methods in Molecular Biology, 1914, 269-280. https://doi.org/10.1007/978-1-4939-8997-3_14
MLA:
Grötsch, Bettina, Aline Bozec, and Georg Schett. "In Vivo Models of Rheumatoid Arthritis." Methods in Molecular Biology 1914 (2019): 269-280.
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