Saying NO to H2S: A Story of HNO, HSNO, and SSNO-

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Ivanovic-Burmazovic I, Filipovic MR
Zeitschrift: Inorganic Chemistry
Jahr der Veröffentlichung: 2019
Band: 58
Heftnummer: 7
Seitenbereich: 4039-4051
ISSN: 0020-1669
eISSN: 1520-510X


Interactions between small inorganic molecules are fundamental to the understanding of basic reaction mechanisms and some of the initial processes of chemical evolution that preceded organic molecules and led to the origin of life. The kinetics of these processes are suitable for the fast generation of a variety of new chemical entities and the propagation of a cascade of chemical reactions, a property that is ideal for signaling purposes even in biological systems. NO and H2S are such molecules that are nowadays recognized as biological gasotransmitters involved in the regulation of physiological functions through protein modifications such as S-nitrosothiol, disulfide, and persulfide formations. In this Viewpoint, we review the current understanding of interactions of NO (and organic and metal nitrosyl species) with H2S, in both chemical and biochemical contexts. Through the formation of HNO, (H)SNO (and its isomers), (H)SSNO, and polysulfides, these two gasotransmitters initiate reaction networks with significant roles in cell signaling. The chemical reactivities and biological effects of these nitrogen and sulfur species are still unresolved, and, thus, a cross-talk between all of them represents a challenging interdisciplinary field that awaits exciting new findings. We tackle some of the intriguing and open questions and provide perspectives for future research directions.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Ivanovic-Burmazovic, Ivana Prof. Dr.
Lehrstuhl für Bioanorganische Chemie

Einrichtungen weiterer Autorinnen und Autoren

Institut national de physique nucléaire et de physique des particules (IN2P3)


Ivanovic-Burmazovic, I., & Filipovic, M.R. (2019). Saying NO to H2S: A Story of HNO, HSNO, and SSNO-. Inorganic Chemistry, 58(7), 4039-4051.

Ivanovic-Burmazovic, Ivana, and Milos R. Filipovic. "Saying NO to H2S: A Story of HNO, HSNO, and SSNO-." Inorganic Chemistry 58.7 (2019): 4039-4051.


Zuletzt aktualisiert 2019-19-08 um 13:08