Psychological long-term outcome in patients with psychogenic nonepileptic seizures

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Walther K, Volbers B, Erdmann L, Onugoren MD, Gollwitzer S, Kasper B, Kurzbuch K, Lang J, Schwab S, Schwarz M, Hamer H
Zeitschrift: Epilepsia
Jahr der Veröffentlichung: 2019
Band: 60
Heftnummer: 4
Seitenbereich: 669-678
ISSN: 0013-9580


Objective To examine the long-term outcome of psychological status, personality, and health-related quality of life (HRQoL) in patients with psychogenic nonepileptic seizures (PNES) and to define predictors of favorable outcome of cessation of PNES. Method Patients diagnosed with PNES during video-electroencephalography (EEG) monitoring at the Erlangen Epilepsy Center were contacted 1-16 years after communicating the diagnosis. Follow-up information from each participant was obtained by interview (PNES outcome) and by self-reported questionnaires of psychological symptoms (Beck Depression Inventory-II, Symptom Checklist-90-Standard, Dissociative Symptoms questionnaire), personality traits (Freiburg Personality Inventory-Revised), and HRQoL (36-Item Short Form Health Survey). Results Fifty-two patients participated in the study (mean age +/- standard deviation [SD] 40.5 +/- 14.0 years; 75% female, follow-up: 5.3 +/- 4.2 years). Nineteen patients (37%) were free of PNES for the past 12 months. Patients with persisting PNES were older at disease onset (32.9 vs 22.3 years, P < 0.01) and diagnosis (40.5 vs 27.2 years, P < 0.001), and showed worse psychological functioning, lower extraversion and life satisfaction, and higher inhibitedness and worse HRQoL than PNES-free patients. Patients with cessation of PNES were within the normal range in all dimensions. Cessation of PNES was best predicted by younger age at PNES onset and higher extraversion. Significance Outcome of PNES is poor, psychopathology is high, and HRQoL is low in patients with persistent PNES but may normalize with PNES cessation. High introversion and older age at PNES onset are risk factors for persistent PNES.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Hamer, Hajo Prof. Dr. med.
Professur für Epileptologie
Kasper, Burkhard Prof. Dr.
Medizinische Fakultät
Kurzbuch, Katrin
Medizinische Fakultät
Schwab, Stefan Prof. Dr.
Lehrstuhl für Neurologie
Schwarz, Michael Dr. rer. biol. hum.
Neurologische Klinik
Volbers, Bastian PD Dr.
Neurologische Klinik


Walther, K., Volbers, B., Erdmann, L., Onugoren, M.D., Gollwitzer, S., Kasper, B.,... Hamer, H. (2019). Psychological long-term outcome in patients with psychogenic nonepileptic seizures. Epilepsia, 60(4), 669-678.

Walther, Katrin, et al. "Psychological long-term outcome in patients with psychogenic nonepileptic seizures." Epilepsia 60.4 (2019): 669-678.


Zuletzt aktualisiert 2019-16-04 um 13:38