ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure

Madonna R, Van Laake LW, Botker HE, Davidson SM, De Caterina R, Engel F, Eschenhagen T, Fernandez-Aviles F, Hausenloy DJ, Hulot JS, Lecour S, Leor J, Menasche P, Pesce M, Perrino C, Prunier F, Van Linthout S, Ytrehus K, Zimmermann WH, Ferdinandy P, Sluijter JPG (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Book Volume: 115

Pages Range: 488-500

Journal Issue: 3

DOI: 10.1093/cvr/cvz010

Abstract

Morbidity and mortality from ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and are increasing worldwide. Patients with IHD or HF might benefit from novel therapeutic strategies, such as cell-based therapies. We recently discussed the therapeutic potential of cell-based therapies and provided recommendations on how to improve the therapeutic translation of these novel strategies for effective cardiac regeneration and repair. Despite major advances in optimizing these strategies with respect to cell source and delivery method, the clinical outcome of cell-based therapy remains unsatisfactory. Major obstacles are the low engraftment and survival rate of transplanted cells in the harmful microenvironment of the host tissue, and the paucity or even lack of endogenous cells with repair capacity. Therefore, new ways of delivering cells and their derivatives are required in order to empower cell-based cardiac repair and regeneration in patients with IHD or HF. Strategies using tissue engineering (TE) combine cells with matrix materials to enhance cell retention or cell delivery in the transplanted area, and have recently received much attention for this purpose. Here, we summarize knowledge on novel approaches emerging from the TE scenario. In particular, we will discuss how combinations of cell/bio-materials (e.g. hydrogels, cell sheets, prefabricated matrices, microspheres, and injectable matrices) combinations might enhance cell retention or cell delivery in the transplantation areas, thereby increase the success rate of cell therapies for IHD and HF. We will not focus on the use of classical engineering approaches, employing fully synthetic materials, because of their unsatisfactory material properties which render them not clinically applicable. The overall aim of this Position Paper from the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to proceed in research with these novel TE strategies combined with cell-based therapies to boost cardiac repair in the clinical settings of IHD and HF.

Involved external institutions

University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) Universidad Complutense de Madrid (UCM) Spain (ES) National University of Singapore (NUS) Singapore (SG) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) France (FR) University of Cape Town (UCT) South Africa (ZA) Tel Aviv University Israel (IL) Georges Pompidou European Hospital / Hôpital Européen Georges-Pompidou (HEGP) France (FR) Istituto di ricovero e cura a carattere scientifico (IRCCS) Italy (IT) Università degli Studi di Napoli Federico II Italy (IT) Université d'Angers France (FR) Charité - Universitätsmedizin Berlin Germany (DE) Universitetet i Tromsø / The Arctic University of Norway (UiT) Norway (NO) Università degli Studi Gabriele D'Annunzio Italy (IT) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) University College London (UCL) United Kingdom (GB) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universitätsklinikum Göttingen Germany (DE) Semmelweis University / Semmelweis Egyetem Hungary (HU) Universiteit Utrecht (UU) / Utrecht University Netherlands (NL)

How to cite

APA:

Madonna, R., Van Laake, L.W., Botker, H.E., Davidson, S.M., De Caterina, R., Engel, F.,... Sluijter, J.P.G. (2019). ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure. Cardiovascular Research, 115(3), 488-500. https://dx.doi.org/10.1093/cvr/cvz010

MLA:

Madonna, Rosalinda, et al. "ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure." Cardiovascular Research 115.3 (2019): 488-500.

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