Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation
Kim SY, Ludwig S, Schneider H, Wixler V, Park J, Völkl S (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 132
Journal Issue: 6
DOI: 10.1242/jcs.228940
Abstract
The four and a half LIM domains protein 2 (Fhl2) is an adaptor protein capable of mediating protein-protein interactions. Here, we report for the first time phenotypic changes in the brain of Fhl2-deficient mice. We showed that Fhl2 is expressed in neural stem cells, precursors and mature cells of neuronal lineage. Moreover, Fhl2 deficiency leads to delayed neuroblast migration in vivo, premature astroglial differentiation of neural stem cells (NSCs) in vitro, and a gliosis-like accumulation of glial fibrillary acidic protein (GFAP)-positive astrocytes in vivo that substantially increases with age. Collectively, Fhl2-deficiency in the brain interrupts the maintenance and the balanced differentiation of adult NSCs, resulting in preferentially glial differentiation and early exhaustion of the NSC pool required for adult neurogenesis.
Authors with CRIS profile
Holm Schneider
Professur für Kinderheilkunde/Experimentelle Perinatalmedizin
Simon Völkl
Department of Medicine 5 – Haematology and Oncology
Involved external institutions
Germany (DE)
Switzerland (CH)How to cite
APA:
Kim, S.Y., Ludwig, S., Schneider, H., Wixler, V., Park, J., & Völkl, S. (2019). Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation. Journal of Cell Science, 132(6). https://doi.org/10.1242/jcs.228940
MLA:
Kim, Soung Yung, et al. "Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation." Journal of Cell Science 132.6 (2019).
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