Sodium chloride triggers Th17 mediated autoimmunity

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Haase S, Wilck N, Kleinewietfeld M, Mueller DN, Linker R
Zeitschrift: Journal of Neuroimmunology
Jahr der Veröffentlichung: 2019
Band: 329
Seitenbereich: 9-13
ISSN: 0165-5728


The detrimental effects of a high-salt diet on human health have received much attention in the past few years. While it has been well established that high dietary salt intake is related to cardiovascular diseases, there is growing evidence that excess salt also affects the immune system and might be considered as a risk factor in autoimmune diseases such as multiple sclerosis (MS). Several studies have implicated T helper 17 cells (Th17) in the pathogenesis of MS. We and others recently demonstrated that excessive salt enhances the differentiation of Th17 cells, inducing a highly pathogenic phenotype that aggravates experimental neuroinflammation. Moreover, a diet rich in sodium affects intestinal microbiota alongside increased intestinal Th17 cells, thus linking the detrimental effects of high salt consumption to the gut-immune axis. First human studies revealed an association of increased MS disease activity with elevated sodium chloride consumption, while more recent epidemiology studies in larger cohorts suggest no correlation between salt intake and MS. However, it is known that ordinary urinary sodium analyses and nutritional questionnaires do not necessarily correspond to the actual sodium load and more sophisticated analyses are needed. Moreover, studies revealed that sodium can temporarily be stored in the body. This review summarizes recent findings on the impact of salt on the immune system and discusses potential challenges investigating dietary salt intake as a risk factor in MS.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Linker, Ralf PD Dr.
Neurologische Klinik

Einrichtungen weiterer Autorinnen und Autoren

Hasselt University / Universiteit Hasselt
Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch


Haase, S., Wilck, N., Kleinewietfeld, M., Mueller, D.N., & Linker, R. (2019). Sodium chloride triggers Th17 mediated autoimmunity. Journal of Neuroimmunology, 329, 9-13.

Haase, Stefanie, et al. "Sodium chloride triggers Th17 mediated autoimmunity." Journal of Neuroimmunology 329 (2019): 9-13.


Zuletzt aktualisiert 2019-10-04 um 13:23