Cartilage regeneration using decellularized cartilage matrix: Long-term comparison of subcutaneous and intranasal placement in a rabbit model

Journal article


Publication Details

Author(s): Von Bomhard A, Elsaesser A, Riepl R, Pippich K, Faust J, Schwarz S, Körber L, Breiter R, Rotter N
Journal: Journal of Cranio-Maxillofacial Surgery
Publication year: 2019
Volume: 47
Journal issue: 4
Pages range: 682-694
ISSN: 1010-5182


Abstract

Autologous cartilage as donor tissue for various surgical reconstructions such as nasal septum regeneration is limited and associated with donor site morbidity. Our goal was to evaluate a new resorbable chondroconductive biomaterial made of decellularized porcine nasal septum cartilage compared with autologous native auricular cartilage as the gold standard. In order to examine the material and determine its long-term outcome further, we used subcutaneous implantation and septal implantation in an orthotopic rabbit model. In addition to non-seeded decellularized xenogenic cartilage, chondrocyte-seeded decellularized xenogenic cartilage was implanted as a septal replacement. After a three- or six-month period, the formation of newly synthesized cartilage extracellular matrix was evaluated immunohistochemically, whereas septal integrity and biocompatibility were evaluated histologically. The formation of the implanted neoseptum and form stability was analyzed by using 7-Tesla Magnetic Resonance Imaging.


FAU Authors / FAU Editors

Breiter, Roman Dr.
Lehrstuhl für Medizinische Biotechnologie
Körber, Ludwig Dr.-Ing.
Lehrstuhl für Bioverfahrenstechnik


External institutions with authors

Klinik Augustinum München
Paracelsus Medizinische Privatuniversität
Technische Universität München (TUM)
Universitätsklinikum Mannheim
Universitätsklinikum Ulm


How to cite

APA:
Von Bomhard, A., Elsaesser, A., Riepl, R., Pippich, K., Faust, J., Schwarz, S.,... Rotter, N. (2019). Cartilage regeneration using decellularized cartilage matrix: Long-term comparison of subcutaneous and intranasal placement in a rabbit model. Journal of Cranio-Maxillofacial Surgery, 47(4), 682-694. https://dx.doi.org/10.1016/j.jcms.2019.01.010

MLA:
Von Bomhard, Achim, et al. "Cartilage regeneration using decellularized cartilage matrix: Long-term comparison of subcutaneous and intranasal placement in a rabbit model." Journal of Cranio-Maxillofacial Surgery 47.4 (2019): 682-694.

BibTeX: 

Last updated on 2019-22-07 at 07:35