Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

Journal article
(Review article)


Publication Details

Author(s): O'Donnell VB, Aldrovandi M, Murphy RC, Krönke G
Journal: Science Signaling
Publication year: 2019
Volume: 12
Journal issue: 574
ISSN: 1937-9145


Abstract

Enzymatically oxidized phospholipids (eoxPLs) are formed through regulated processes by which eicosanoids or prostaglandins are attached to phospholipids (PLs) in immune cells. These eoxPLs comprise structurally diverse families of biomolecules with potent bioactivities, and they have important immunoregulatory roles in both health and disease. The formation of oxPLs through enzymatic pathways and their signaling capabilities are emerging concepts. This paradigm is changing our understanding of eicosanoid, prostaglandin, and PL biology in health and disease. eoxPLs have roles in cellular events such as ferroptosis, apoptosis, and blood clotting and diseases such as arthritis, diabetes, and cardiovascular disease. They are increasingly recognized as endogenous bioactive mediators and potential targets for drug development. This review will describe recent evidence that places eoxPLs and their biosynthetic pathways center stage in immunoregulation.


FAU Authors / FAU Editors

Krönke, Gerhard Prof. Dr. med.
Medizinische Klinik 3 - Rheumatologie und Immunologie


External institutions
Cardiff University
University of Colorado System


How to cite

APA:
O'Donnell, V.B., Aldrovandi, M., Murphy, R.C., & Krönke, G. (2019). Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death. Science Signaling, 12(574). https://dx.doi.org/10.1126/scisignal.aau2293

MLA:
O'Donnell, Valerie B., et al. "Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death." Science Signaling 12.574 (2019).

BibTeX: 

Last updated on 2019-09-04 at 19:08

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