Immunoregulatory role of acid sphingomyelinase in allergic asthma

Journal article


Publication Details

Author(s): Sopel N, Kölle J, Dumendiak S, Koch S, Reichel M, Rhein C, Kornhuber J, Finotto S
Journal: Immunology
Publication year: 2019
Volume: 156
Journal issue: 4
Pages range: 373-383
ISSN: 0019-2805


Abstract

Acid sphingomyelinase (ASM) is one of the enzymes that catalyzes the breakdown of sphingomyelin to ceramide and phosphorylcholine. In this study, we aimed at elucidating the role of ASM in allergic asthma. We used an ovalbumin-induced murine model of asthma where we compared wild-type and ASM-deficient mice. In wild-type mice, secretory ASM activity in the bronchoalveolar lavage fluid was increased in the acute ovalbumin model, but not in a tolerogenic model. Furthermore, in the absence of ASM, the serum IgE level was reduced, compared with wild-type mice, while an accumulation of interstitial macrophages and foreign antigen-induced regulatory T cells along with exhausted CD4(+) PD1(+) T cells was observed in the lungs of ASM(-/-) mice. In conclusion, in the absence of ASM, we observed an accumulation of immunosuppressive antigen-induced regulatory T cells expressing Foxp3 and CTLA4 in the lung as well as multinucleated interstitial macrophages and exhausted CD4(+) PD1(+) T cells associated with inhibition of serum IgE in asthma.


FAU Authors / FAU Editors

Koch, Sonja Dr. rer. nat.
Molekular-Pneumologische Abteilung
Kölle, Julia
Molekular-Pneumologische Abteilung
Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Rhein, Cosima PD Dr.
Psychiatrische und Psychotherapeutische Klinik
Sopel, Nina Dr. rer. nat.
Molekular-Pneumologische Abteilung


External institutions with authors

Charité - Universitätsmedizin Berlin


How to cite

APA:
Sopel, N., Kölle, J., Dumendiak, S., Koch, S., Reichel, M., Rhein, C.,... Finotto, S. (2019). Immunoregulatory role of acid sphingomyelinase in allergic asthma. Immunology, 156(4), 373-383. https://dx.doi.org/10.1111/imm.13035

MLA:
Sopel, Nina, et al. "Immunoregulatory role of acid sphingomyelinase in allergic asthma." Immunology 156.4 (2019): 373-383.

BibTeX: 

Last updated on 2019-10-04 at 13:38