5-HT3A serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease

Journal article


Publication Details

Author(s): De Oliveira JA, Freitas MAR, De Oliveira EC, Jabari S, Brehmer A, Morais Da Silveira AB
Journal: Parasitology Research
Publication year: 2019
Volume: 118
Journal issue: 4
Pages range: 1325-1329
ISSN: 0932-0113


Abstract

Chagas disease is caused by Trypanosoma cruzi and remains one of the most neglected diseases in Latin America. One of its clinical forms is Chagas megacolon. Despite being known for more than half a century, detailed causes are still obscure. Recent evidence indicates a close relationship between the immune system and the enteric nervous system in the etiology of chagasic megacolon pathology. It is believed that low expression of the 5-HT3A serotonin receptor on lymphocytes could be linked to megacolon development. To test this hypothesis, this work investigated the distribution of CD4, CD8, and CD20 lymphocytes and their 5-HT3A receptor expression. The results demonstrated that Chagas patients without megacolon present a higher expression of the 5-HT3A receptor in all analyzed lymphocytes compared with Chagas patients with megacolon. These data suggest that the high expression of this receptor may lead to immunomodulation and prevent the development of Chagas megacolon.


FAU Authors / FAU Editors

Brehmer, Axel Prof. Dr.
Lehrstuhl für Anatomie und Zellbiologie
Jabari, Samir PD Dr.
Lehrstuhl für Anatomie und Zellbiologie


External institutions
UFG - Universidade Federal de Goiás
Universidade Federal Uberlândia


How to cite

APA:
De Oliveira, J.A., Freitas, M.A.R., De Oliveira, E.C., Jabari, S., Brehmer, A., & Morais Da Silveira, A.B. (2019). 5-HT3A serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease. Parasitology Research, 118(4), 1325-1329. https://dx.doi.org/10.1007/s00436-019-06241-w

MLA:
De Oliveira, Jefferson Alvim, et al. "5-HT3A serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease." Parasitology Research 118.4 (2019): 1325-1329.

BibTeX: 

Last updated on 2019-09-04 at 15:08