5-HT3A serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease

De Oliveira JA, Freitas MAR, De Oliveira EC, Jabari S, Brehmer A, Morais Da Silveira AB (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Parasitology Research Springer Verlag (Germany)

Book Volume: 118

Pages Range: 1325-1329

Journal Issue: 4

DOI: 10.1007/s00436-019-06241-w

Abstract

Chagas disease is caused by Trypanosoma cruzi and remains one of the most neglected diseases in Latin America. One of its clinical forms is Chagas megacolon. Despite being known for more than half a century, detailed causes are still obscure. Recent evidence indicates a close relationship between the immune system and the enteric nervous system in the etiology of chagasic megacolon pathology. It is believed that low expression of the 5-HT3A serotonin receptor on lymphocytes could be linked to megacolon development. To test this hypothesis, this work investigated the distribution of CD4, CD8, and CD20 lymphocytes and their 5-HT3A receptor expression. The results demonstrated that Chagas patients without megacolon present a higher expression of the 5-HT3A receptor in all analyzed lymphocytes compared with Chagas patients with megacolon. These data suggest that the high expression of this receptor may lead to immunomodulation and prevent the development of Chagas megacolon.

Authors with CRIS profile

Samir Jabari Lehrstuhl für Mikroskopische Anatomie und Molekulare Zellbiologie Axel Brehmer Lehrstuhl für Mikroskopische Anatomie und Molekulare Zellbiologie

Involved external institutions

Universidade Federal Uberlândia BR Brazil (BR) UFG - Universidade Federal de Goiás BR Brazil (BR)

How to cite

APA:

De Oliveira, J.A., Freitas, M.A.R., De Oliveira, E.C., Jabari, S., Brehmer, A., & Morais Da Silveira, A.B. (2019). 5-HT3A serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease. Parasitology Research, 118(4), 1325-1329. https://dx.doi.org/10.1007/s00436-019-06241-w

MLA:

De Oliveira, Jefferson Alvim, et al. "5-HT3A serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease." Parasitology Research 118.4 (2019): 1325-1329.

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