Non-Clear Cell Renal Cell Carcinoma - Pathology and Treatment Options
Ahrens M, Scheich S, Hartmann A, Bergmann L (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 42
Pages Range: 128-135
Journal Issue: 3
DOI: 10.1159/000495366
Abstract
Non-clear cell renal cell carcinomas (nccRCC) are rare diseases with heterogeneous histopathologically and genetically defined entities. The clinical data on optimal systemic treatments of nccRCC is rather limited. In this review, the current World Health Organization (WHO) classification of nccRCC based on histopathologic and genetic findings is reported. Regarding systemic treatment options, the most commonly used agents are mTOR inhibitors like everolimus or temsirolimus, or tyrosine kinase inhibitors like sunitinib. 2 small randomized clinical trials with nccRCC comparing sunitinib with everolimus revealed a trend towards a better progression-free survival (PFS) and overall survival (OS) in favor of sunitinib. In RCC with predominant sarcomatoid features, both chemotherapy and targeted agents are reported without any preference for outcome. For subsequent lines of therapy, some case reports describe promising effects of PD-1 or PD-L1 inhibitors in nccRCC including sarcomatoid subtype and Bellini duct carcinoma. Currently, nccRCCs are treated similarly to clear cell RCC or, whenever possible, within clinical trials. Clinical trials with immune checkpoint inhibitors are ongoing. (c) 2019 S. Karger AG, Basel
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Ahrens, M., Scheich, S., Hartmann, A., & Bergmann, L. (2019). Non-Clear Cell Renal Cell Carcinoma - Pathology and Treatment Options. Oncology Research and Treatment, 42(3), 128-135. https://dx.doi.org/10.1159/000495366
MLA:
Ahrens, Marit, et al. "Non-Clear Cell Renal Cell Carcinoma - Pathology and Treatment Options." Oncology Research and Treatment 42.3 (2019): 128-135.
BibTeX: Download