Rhinovirus Species-Specific Antibodies Differentially Reflect Clinical Outcomes in Health and Asthma

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Megremis S, Niespodziana K, Cabauatan C, Xepapadaki P, Kowalski ML, Jartti T, Bachert C, Finotto S, West P, Stamataki S, Lewandowska-Polak A, Lukkarinen H, Zhang N, Zimmermann T, Stolz F, Neubauer A, Akdis M, Andreakos E, Valenta R, Papadopoulos NG
Zeitschrift: American Journal of Respiratory and Critical Care Medicine
Jahr der Veröffentlichung: 2018
Band: 198
Heftnummer: 12
Seitenbereich: 1490-1499
ISSN: 1073-449X


Abstract

RATIONALE: Rhinoviruses are major triggers of common cold and acute asthma exacerbations; Rhinovirus species A, B and C may have distinct clinical impact; however, little is known regarding RV species-specific antibody responses in health and asthma.
OBJECTIVES: To describe and compare total and rhinovirus species-specific antibody levels in healthy and asthmatic children, away from an acute event.
METHODS: Serum samples from 163 preschool children with mild to moderate asthma and 72 healthy controls from the multinational Predicta cohort were analysed using the recently developed PreDicta rhinovirus antibody chip.
MAIN RESULTS: Rhinovirus antibody levels varied, with rhinovirus C and rhinovirus A being higher than rhinovirus B in both groups. Compared to controls, asthma was characterised by significantly higher levels of antibodies to rhinovirus A and rhinovirus C, but not rhinovirus B. Rhinovirus antibody levels positively correlated with the number of common colds over the previous year in healthy children, and wheeze episodes in asthmatics. Antibody levels also positively correlated with asthma severity but not with current asthma control.
CONCLUSIONS: The variable humoral response to rhinovirus species in both groups, suggests a differential infectivity pattern between rhinovirus species. In healthy pre-schoolers, rhinovirus antibodies accumulate with colds. In asthma, rhinovirus A and rhinovirus C antibodies are much higher and further increase with disease severity and wheeze episodes. Higher antibody levels in asthma may be due to a compromised innate immune response, leading to increased exposure of the adaptive immunity to the virus. Importantly, there is no apparent protection with increasing levels of antibodies.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Zimmermann, Theodor apl. Prof. Dr.
Medizinische Fakultät


Zusätzliche Organisationseinheit(en)
Molekular-Pneumologische Abteilung


Einrichtungen weiterer Autorinnen und Autoren

Academy of Athens / Ακαδημία Αθηνών
Athens General Children’s Hospital “Pan. & Aglaia Kyriakou”
Biomay AG

Medical University of Łódź / Uniwersytet Medyczny w Łodzi
Medizinische Universität Wien
National and Kapodistrian University of Athens
Universität Zürich (UZH)
Universiteit Gent (UGent) / Ghent University
University of Manchester
University of Turku / Turun yliopisto


Zitierweisen

APA:
Megremis, S., Niespodziana, K., Cabauatan, C., Xepapadaki, P., Kowalski, M.L., Jartti, T.,... Papadopoulos, N.G. (2018). Rhinovirus Species-Specific Antibodies Differentially Reflect Clinical Outcomes in Health and Asthma. American Journal of Respiratory and Critical Care Medicine, 198(12), 1490-1499. https://dx.doi.org/10.1164/rccm.201803-0575OC

MLA:
Megremis, Spyridon, et al. "Rhinovirus Species-Specific Antibodies Differentially Reflect Clinical Outcomes in Health and Asthma." American Journal of Respiratory and Critical Care Medicine 198.12 (2018): 1490-1499.

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Zuletzt aktualisiert 2019-08-04 um 09:19