Update Breast Cancer 2019 Part 1-Implementation of Study Results of Novel Study Designs in Clinical Practice in Patients with Early Breast Cancer

Hartkopf AD, Mueller V, Woeckel A, Lux MP, Janni W, Nabieva N, Taran FA, Ettl J, Lueftner D, Belleville E, Schuetz F, Fasching P, Fehm TN, Kolberg HC, Overkamp F, Schneeweiss A, Tesch H (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Geburtshilfe und Frauenheilkunde Georg Thieme Verlag

Book Volume: 79

Pages Range: 256-267

Journal Issue: 3

DOI: 10.1055/a-0842-6614

Abstract

For many years, small but significant advancements have been made time and again in the prevention and treatment of early breast cancer. The so-called panel gene analyses are becoming more and more important in prevention, since the risk due to the tested genes is better understood and as a result, concepts for integration in health care can be developed. In the adjuvant situation, the first study in the so-called post-neoadjuvant situation was able to demonstrate a clear improvement in the prognosis with an absent pathological complete remission following trastuzumab or pertuzumab + trastuzumab. Additional studies with this post-neoadjuvant therapeutic concept are still being conducted at present. The CDK4/6 inhibitors which had shown a significant improvement in progression-free survival in a metastatic situation are currently being tested in the adjuvant situation in large therapeutic studies. These and other new data for the treatment or prevention of primary breast cancer are presented in this review against the backdrop of current studies.

Authors with CRIS profile

Naiba Nabieva Department of Obstetrics and Gynaecology Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Eberhard Karls Universität Tübingen DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) ClinSol GmbH & Co.KG DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) Marienhospital Bottrop DE Germany (DE) OncoConsult DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Centrum für Hämatologie und Onkologie Bethanien DE Germany (DE)

How to cite

APA:

Hartkopf, A.D., Mueller, V., Woeckel, A., Lux, M.P., Janni, W., Nabieva, N.,... Tesch, H. (2019). Update Breast Cancer 2019 Part 1-Implementation of Study Results of Novel Study Designs in Clinical Practice in Patients with Early Breast Cancer. Geburtshilfe und Frauenheilkunde, 79(3), 256-267. https://dx.doi.org/10.1055/a-0842-6614

MLA:

Hartkopf, Andreas D., et al. "Update Breast Cancer 2019 Part 1-Implementation of Study Results of Novel Study Designs in Clinical Practice in Patients with Early Breast Cancer." Geburtshilfe und Frauenheilkunde 79.3 (2019): 256-267.

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