Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Wunderle M, Pretscher J, Brucker SY, Volz B, Hartmann A, Fiessler C, Hein A, Häberle L, Jud S, Lux MP, Janni W, Löhberg C, Hartkopf AD, Walter CB, Baake G, Fridman A, Malter W, Wuerstlein R, Harbeck N, Hoffmann O, Kuemmel S, Martin B, Thomssen C, Graf H, Wolf C, Bayer CM, Hack C, Almstedt K, Gaß P, Heindl F, Brodkorb TF, Nabieva N, Lindner C, Kolberg HC, Krabisch P, Weigel M, Steinfeld-Birg D, Kohls A, Brucker C, Schulz V, Fischer G, Pelzer V, Wallwiener D, Rack B, Fehm T, Rody A, Maass N, Beckmann M, Fasching P, Rauh C
Zeitschrift: Breast Cancer Research and Treatment
Jahr der Veröffentlichung: 2019
Band: 174
Heftnummer: 2
Seitenbereich: 453-461
ISSN: 0167-6806


Abstract

PurposeEvidence shows that genetic and non-genetic risk factors for breast cancer (BC) differ relative to the molecular subtype. This analysis aimed to investigate associations between epidemiological risk factors and immunohistochemical subtypes in a cohort of postmenopausal, hormone receptor-positive BC patients.MethodsThe prospective, single-arm, multicenter phase IV PreFace study (Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy) included 3529 postmenopausal patients with hormone receptor-positive early BC. Data on their epidemiological risk factors were obtained from patients' diaries and their medical histories. Data on estrogen receptor, progesterone receptor, and HER2 receptor status were obtained from pathology reports. Patients with incomplete information were excluded. Data were analyzed using conditional inference regression analysis, analysis of variance, and the chi-squared test.ResultsIn a cohort of 3392 patients, the strongest association with the molecular subtypes of BC was found for hormone replacement therapy (HRT) before diagnosis of early BC. The analysis showed that patients who took HRT at diagnosis had luminal A-like BC more often (83.7%) than those who had never taken HRT or had stopped taking it (75.5%). Luminal B-like BC and HER2-positive BC were diagnosed more often in women who had never taken HRT or had stopped taking it (13.3% and 11.2%, respectively) than in women who were taking HRT at diagnosis of BC (8.3% and 8.0%, respectively).ConclusionsThis analysis shows an association between HRT and the distribution of molecular subtypes of BC. However, no associations between other factors (e.g., age at diagnosis, body mass index, smoking status, age at menopause, number of deliveries, age at first delivery, breastfeeding history, or family history) were noted.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe
Fiessler, Cornelia
Lehrstuhl für Biometrie und Epidemiologie
Gaß, Paul Dr. med.
Frauenklinik
Hack, Carolin PD Dr.
Medizinische Fakultät
Hartmann, Arndt Prof. Dr. med.
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Hein, Alexander PD Dr.
Frauenklinik
Heindl, Felix
Medizinische Fakultät
Jud, Sebastian Dr.
Frauenklinik
Nabieva, Naiba Dr. med.
Frauenklinik
Wunderle, Marius
Professur für Translationale Frauenheilkunde und Geburtshilfe


Einrichtungen weiterer Autorinnen und Autoren

abts+partner Partnerschaftsgesellschaft
AGAPLESION DIAKONIEKLINIKUM HAMBURG gemeinnützige GmbH
Eberhard Karls Universität Tübingen
Evangelisches Krankenhaus Ludwigsfelde-Teltow
Heinrich-Heine-Universität Düsseldorf
HELIOS Kliniken
Johannes Gutenberg-Universität Mainz
Kliniken Essen-Mitte
Klinikum Chemnitz
Klinikum Landkreis Tuttlingen
Landkreis Mittweida Krankenhaus
Leopoldina Krankenhaus Schweinfurt
Ludwig-Maximilians-Universität (LMU)
Marienhospital Bottrop
Martin-Luther-Universität Halle-Wittenberg (MLU)
Onkologische Praxis Pinneberg
Paracelsus Medizinische Privatuniversität, Nürnberg
St.-Marien-Hospital Bonn
Universität Duisburg-Essen (UDE)
Universitätsklinikum Köln
Universitätsklinikum Schleswig-Holstein (UKSH)
Universitätsklinikum Ulm


Zitierweisen

APA:
Wunderle, M., Pretscher, J., Brucker, S.Y., Volz, B., Hartmann, A., Fiessler, C.,... Rauh, C. (2019). Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer. Breast Cancer Research and Treatment, 174(2), 453-461. https://dx.doi.org/10.1007/s10549-018-05115-6

MLA:
Wunderle, Marius, et al. "Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer." Breast Cancer Research and Treatment 174.2 (2019): 453-461.

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Zuletzt aktualisiert 2019-01-04 um 09:08