Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer

Wunderle M, Pretscher J, Brucker SY, Volz B, Hartmann A, Fießler C, Hein A, Häberle L, Jud S, Lux MP, Janni W, Löhberg C, Hartkopf AD, Walter CB, Baake G, Fridman A, Malter W, Wuerstlein R, Harbeck N, Hoffmann O, Kuemmel S, Martin B, Thomssen C, Graf H, Wolf C, Bayer CM, Hack C, Almstedt K, Gaß P, Heindl F, Brodkorb TF, Nabieva N, Lindner C, Kolberg HC, Krabisch P, Weigel M, Steinfeld-Birg D, Kohls A, Brucker C, Schulz V, Fischer G, Pelzer V, Wallwiener D, Rack B, Fehm T, Rody A, Maass N, Beckmann M, Fasching P, Rauh C (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Breast Cancer Research and Treatment Springer Verlag (Germany)

Book Volume: 174

Pages Range: 453-461

Journal Issue: 2

DOI: 10.1007/s10549-018-05115-6

Abstract

PurposeEvidence shows that genetic and non-genetic risk factors for breast cancer (BC) differ relative to the molecular subtype. This analysis aimed to investigate associations between epidemiological risk factors and immunohistochemical subtypes in a cohort of postmenopausal, hormone receptor-positive BC patients.MethodsThe prospective, single-arm, multicenter phase IV PreFace study (Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy) included 3529 postmenopausal patients with hormone receptor-positive early BC. Data on their epidemiological risk factors were obtained from patients' diaries and their medical histories. Data on estrogen receptor, progesterone receptor, and HER2 receptor status were obtained from pathology reports. Patients with incomplete information were excluded. Data were analyzed using conditional inference regression analysis, analysis of variance, and the chi-squared test.ResultsIn a cohort of 3392 patients, the strongest association with the molecular subtypes of BC was found for hormone replacement therapy (HRT) before diagnosis of early BC. The analysis showed that patients who took HRT at diagnosis had luminal A-like BC more often (83.7%) than those who had never taken HRT or had stopped taking it (75.5%). Luminal B-like BC and HER2-positive BC were diagnosed more often in women who had never taken HRT or had stopped taking it (13.3% and 11.2%, respectively) than in women who were taking HRT at diagnosis of BC (8.3% and 8.0%, respectively).ConclusionsThis analysis shows an association between HRT and the distribution of molecular subtypes of BC. However, no associations between other factors (e.g., age at diagnosis, body mass index, smoking status, age at menopause, number of deliveries, age at first delivery, breastfeeding history, or family history) were noted.

Authors with CRIS profile

Marius Wunderle Professur für Translationale Frauenheilkunde und Geburtshilfe Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Cornelia Fießler Lehrstuhl für Biometrie und Epidemiologie Alexander Hein Department of Obstetrics and Gynaecology Sebastian Jud Department of Obstetrics and Gynaecology Christian Löhberg Department of Obstetrics and Gynaecology Carolin Hack Medizinische Fakultät Paul Gaß Department of Obstetrics and Gynaecology Felix Heindl Medizinische Fakultät Naiba Nabieva Department of Obstetrics and Gynaecology Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Landkreis Mittweida Krankenhaus DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE) Agaplesion Diakonieklinikum Hamburg DE Germany (DE) Evangelisches Krankenhaus Ludwigsfelde-Teltow DE Germany (DE) Leopoldina Krankenhaus Schweinfurt DE Germany (DE) abts+partner Partnerschaftsgesellschaft DE Germany (DE) Paracelsus Medizinische Privatuniversität, Nürnberg DE Germany (DE) Universitätsklinikum Köln DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE) Onkologische Praxis Pinneberg DE Germany (DE) Heinrich-Heine-Universität Düsseldorf DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Klinikum Chemnitz DE Germany (DE) Marienhospital Bottrop DE Germany (DE) HELIOS Kliniken DE Germany (DE) Kliniken Essen-Mitte DE Germany (DE) St.-Marien-Hospital Bonn DE Germany (DE) Klinikum Landkreis Tuttlingen DE Germany (DE) Universität Duisburg-Essen (UDE) DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE)

How to cite

APA:

Wunderle, M., Pretscher, J., Brucker, S.Y., Volz, B., Hartmann, A., Fießler, C.,... Rauh, C. (2019). Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer. Breast Cancer Research and Treatment, 174(2), 453-461. https://dx.doi.org/10.1007/s10549-018-05115-6

MLA:

Wunderle, Marius, et al. "Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer." Breast Cancer Research and Treatment 174.2 (2019): 453-461.

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