Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis

Journal article


Publication Details

Author(s): Comi G, Cook S, Giovannoni G, Rieckmann P, Sorensen PS, Vermersch P, Galazka A, Nolting A, Hicking C, Dangond F
Journal: Multiple Sclerosis and Related Disorders
Publication year: 2019
Volume: 29
Pages range: 168-174
ISSN: 2211-0348


Abstract

Background: Immune reconstitution therapies (IRT) for patients with multiple sclerosis are used for short, intermittent treatment periods to induce immune resetting and allow subsequent treatment-free periods. Cladribine tablets are postulated to be an IRT that causes selective and transient reductions in CD19(+) B cells and T cells, followed by reconstitution of adaptive immune function.


Additional Organisation
Neurologische Klinik


External institutions with authors

EMD Serono
LILLE 1 University - Science and Technology
Medical Park AG
Merck KGaA
Merck Sharp & Dohme Corp
Queen Mary, University of London
The State University of New Jersey (Rutgers)
Università Vita-Salute San Raffaele (UniSR)
University of Copenhagen


How to cite

APA:
Comi, G., Cook, S., Giovannoni, G., Rieckmann, P., Sorensen, P.S., Vermersch, P.,... Dangond, F. (2019). Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis. Multiple Sclerosis and Related Disorders, 29, 168-174. https://dx.doi.org/10.1016/j.msard.2019.01.038

MLA:
Comi, Giancarlo, et al. "Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis." Multiple Sclerosis and Related Disorders 29 (2019): 168-174.

BibTeX: 

Last updated on 2019-01-04 at 09:17