Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis

Comi G, Cook S, Giovannoni G, Rieckmann P, Sorensen PS, Vermersch P, Galazka A, Nolting A, Hicking C, Dangond F (2019)


Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 29

Pages Range: 168-174

DOI: 10.1016/j.msard.2019.01.038

Abstract

Background: Immune reconstitution therapies (IRT) for patients with multiple sclerosis are used for short, intermittent treatment periods to induce immune resetting and allow subsequent treatment-free periods. Cladribine tablets are postulated to be an IRT that causes selective and transient reductions in CD19(+) B cells and T cells, followed by reconstitution of adaptive immune function.

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How to cite

APA:

Comi, G., Cook, S., Giovannoni, G., Rieckmann, P., Sorensen, P.S., Vermersch, P.,... Dangond, F. (2019). Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis. Multiple Sclerosis and Related Disorders, 29, 168-174. https://dx.doi.org/10.1016/j.msard.2019.01.038

MLA:

Comi, Giancarlo, et al. "Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis." Multiple Sclerosis and Related Disorders 29 (2019): 168-174.

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