Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial

Alexandrov A, Köhrmann M, Soinne L, Tsivgoulis G, Barreto AD, Demchuk AM, Sharma VK, Mikulik R, Muir KW, Brandt G, Alleman J, Grotta JC, Levi CR, Molina CA, Saqqur M, Mavridis D, Psaltopoulou T, Vosko M, Fiebach JB, Mandava P, Kent TA, Alexandrov AW, Schellinger PD (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 18

Pages Range: 338-347

Journal Issue: 4

DOI: 10.1016/s1474-4422(19)30026-2

Abstract

Background Pulsed-wave ultrasound increases the exposure of an intracranial thrombus to alteplase (recombinant tissue plasminogen activator), potentially facilitating early reperfusion. We aimed to ascertain if a novel operator-independent transcranial ultrasound device delivering low-power high-frequency ultrasound could improve functional outcome in patients treated with alteplase after acute ischaemic stroke.

Authors with CRIS profile

Involved external institutions

University of Tennessee (UTK) United States (USA) (US) University of Alberta Canada (CA) Helsingin yliopisto / University of Helsinki Finland (FI) University of Texas Health Science Center at Houston (UTHealth) United States (USA) (US) University of Calgary Canada (CA) National University of Singapore (NUS) Singapore (SG) St. Anne's University Hospital / Sv. Anny v Brně Czech Republic (CZ) University of Glasgow United Kingdom (GB) Cerevast Medical, Inc. United States (USA) (US) Houston Texas Medical Center United States (USA) (US) University of Newcastle (UoN) Australia (AU) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona Spain (ES) University of Ioannina / Πανεπιστήμιο Ιωαννίνων Greece (GR) National and Kapodistrian University of Athens Greece (GR) Kepler Universitätsklinikum (KUK) Austria (AT) Charité - Universitätsmedizin Berlin Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE)

How to cite

APA:

Alexandrov, A., Köhrmann, M., Soinne, L., Tsivgoulis, G., Barreto, A.D., Demchuk, A.M.,... Schellinger, P.D. (2019). Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurology, 18(4), 338-347. https://dx.doi.org/10.1016/s1474-4422(19)30026-2

MLA:

Alexandrov, Andrei, et al. "Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial." Lancet Neurology 18.4 (2019): 338-347.

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