A novel bone substitute with high bioactivity, strength, and porosity for repairing large and load-bearing bone defects

Journal article
(Original article)


Publication Details

Author(s): Li JJ, Dunstan C, Entezari A, Li Q, Steck R, Saifzadeh S, Sadeghpour A, Field JR, Akey A, Vielreicher M, Friedrich O, Esfahani SI, Zreiqat H
Journal: Advanced healthcare materials
Publication year: 2019
ISSN: 2192-2640
eISSN: 2192-2659
Language: English


Abstract

Achieving adequate healing in large or load-bearing bone defects is
highly challenging even with surgical intervention. The clinical
standard of repairing bone defects using autografts or allografts has
many drawbacks. A bioactive ceramic scaffold,
strontium-hardystonite-gahnite or "Sr-HT-Gahnite" (a multi-component,
calcium silicate-based ceramic) is developed, which when 3D-printed
combines high strength with outstanding bone regeneration ability. In
this study, the performance of purely synthetic, 3D-printed
Sr-HT-Gahnite scaffolds is assessed in repairing large and load-bearing
bone defects. The scaffolds are implanted into critical-sized segmental
defects in sheep tibia for 3 and 12 months, with bone autografts used
for comparison. The scaffolds induce substantial bone formation and
defect bridging after 12 months, as indicated by X-ray, micro-computed
tomography, and histological and biomechanical analyses. Detailed
analysis of the bone-scaffold interface using focused ion beam scanning
electron microscopy and multiphoton microscopy shows scaffold
degradation and maturation of the newly formed bone. In silico modeling
of strain energy distribution in the scaffolds reveal the importance of
surgical fixation and mechanical loading on long-term bone regeneration.
The clinical application of 3D-printed Sr-HT-Gahnite scaffolds as a
synthetic bone substitute can potentially improve the repair of
challenging bone defects and overcome the limitations of bone graft
transplantation.


FAU Authors / FAU Editors

Friedrich, Oliver Prof. Dr. Dr.
Lehrstuhl für Medizinische Biotechnologie
Vielreicher, Martin Dr.
Lehrstuhl für Medizinische Biotechnologie


External institutions with authors

Harvard University
Queensland University of Technology (QUT)
University of Adelaide
University of New South Wales (UNSW)
University of Sydney


How to cite

APA:
Li, J.J., Dunstan, C., Entezari, A., Li, Q., Steck, R., Saifzadeh, S.,... Zreiqat, H. (2019). A novel bone substitute with high bioactivity, strength, and porosity for repairing large and load-bearing bone defects. Advanced healthcare materials. https://dx.doi.org/10.1002/adhm.201801298

MLA:
Li, Jiao Jiao, et al. "A novel bone substitute with high bioactivity, strength, and porosity for repairing large and load-bearing bone defects." Advanced healthcare materials (2019).

BibTeX: 

Last updated on 2019-07-06 at 12:53